Ethyl 4-chloro-2-methylquinoline-3-carboxylate

Base Information

Chemical Name:Ethyl 4-chloro-2-methylquinoline-3-carboxylate
CAS No.:50593-70-9
Molecular Formula:C13H12ClNO2
Molecular Weight:249.69300
Hs Code.:2933499090
DSSTox Substance ID:DTXSID001188158
Mol file:50593-70-9.mol

Synonyms:ETHYL 4-CHLORO-2-METHYLQUINOLINE-3-CARBOXYLATE;50593-70-9;Ethyl 4-chloro-2-methyl-quinoline-3-carboxylate;SCHEMBL1468948;UASKCSYIRXPZPX-UHFFFAOYSA-N;DTXSID001188158;AB50482;ethyl 4-chloro-2-methylquinolin-3-carboxylate;3-QUINOLINECARBOXYLIC ACID, 4-CHLORO-2-METHYL-, ETHYL ESTER

Suppliers and Price of Ethyl 4-chloro-2-methylquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL-4-CHLORO-2-METHYLQUINOLINE-3-CARBOXYLATE 95.00%
5MG
$ 501.92

Total 3 raw suppliers

Chemical Property of Ethyl 4-chloro-2-methylquinoline-3-carboxylate

Chemical Property:

PSA：39.19000
LogP:3.37330
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:249.0556563
Heavy Atom Count:17
Complexity:285

Purity/Quality:

98%min ^*data from raw suppliers

ETHYL-4-CHLORO-2-METHYLQUINOLINE-3-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(C2=CC=CC=C2N=C1C)Cl

Technology Process of Ethyl 4-chloro-2-methylquinoline-3-carboxylate

There total 9 articles about Ethyl 4-chloro-2-methylquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 86769-10-0
ethyl ester of 2-methyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

: 50593-70-9
4-chloro-2-methylquinoline-3-carboxylic acid ethyl ester

Guidance literature:: With trichlorophosphate; for 0.75h; Heating;
DOI:10.1016/S0968-0896(01)00332-7

Reference yield: 86.0%

: 73987-39-0
ethyl 2-methyl-4-hydroxy-3-quinoline-carboxylate

: 50593-70-9
4-chloro-2-methylquinoline-3-carboxylic acid ethyl ester

Guidance literature:: With trichlorophosphate; at 110 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1021/jm300040p

Reference yield:

: 81022-80-2
diethyl 2-(1-(phenylamino)ethylidene)malonate

: 50593-70-9
4-chloro-2-methylquinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.03 g / diphenyl ether / 1 h / 250 °C

2: 76 percent / thionyl chloride; DMF / 1 h / 80 °C

With thionyl chloride; N,N-dimethyl-formamide; In diphenylether;
DOI:10.1021/jm060262x