3-(4-METHOXYBENZOYL)THIOPHENE

Base Information

• Chemical Name: 3-(4-METHOXYBENZOYL)THIOPHENE
• CAS No.: 5064-00-6
• Molecular Formula: C12H10O2S
• Molecular Weight: 218.276
• Hs Code.: 2934999090
• Mol file: 5064-00-6.mol

Synonyms:3-(p-anisoyl)thiophene;Methanone,(4-methoxyphenyl)-3-thienyl;(4-methoxy-phenyl)-thiophen-3-yl-methanone;3-(4-Methoxy-benzoyl)-thiophen;3-(4-METHOXYBENZOYL)THIOPHENE;3-(4-anisoyl)-thiophene;

Chemical Property of 3-(4-METHOXYBENZOYL)THIOPHENE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 353.291oC at 760 mmHg
• Flash Point: 167.465oC
• PSA: 54.54000
• Density: 1.206g/cm3
• LogP: 2.98770

Purity/Quality:

97% ^*data from raw suppliers

3-(4-methoxybenzoyl)thiophene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-METHOXYBENZOYL)THIOPHENE

There total 7 articles about 3-(4-METHOXYBENZOYL)THIOPHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

C20H19NO3S2 → (4-methoxyphenyl)(thiophen-3-yl)methanone (5064-00-6)

Guidance literature:

With oxygen; caesium carbonate; In toluene; Inert atmosphere;

DOI:10.1021/acs.joc.7b03068

Reference yield: 69.0%

(2-aminothiophen-3-yl)(4-methoxyphenyl)methanone (436093-36-6) → (4-methoxyphenyl)(thiophen-3-yl)methanone (5064-00-6)

Guidance literature:

With isopentyl nitrite; In tetrahydrofuran; at 120 ℃; for 0.333333h; under 5250.53 Torr;

DOI:10.3390/molecules24101996

Reference yield: 69.0%

Thien-3-ylboronic acid (6165-69-1) + p-Methoxybenzoic anhydride (794-94-5) → (4-methoxyphenyl)(thiophen-3-yl)methanone (5064-00-6)

Guidance literature:

With potassium phosphate; chloro(1-naphthyl)bis(triphenylphosphine)nickel(II); tricyclohexylphosphine; In toluene; at 50 ℃; for 12h;

DOI:10.1039/c4ra11520a

upstream raw materials:

3-Bromothiophene

4-methoxybenzonitrile

n-butyllithium

Thien-3-ylboronic acid

Downstream raw materials:

4-(4-hydroxybenzoyl)thiophene-2-sulfonamide

4-(4-Methoxy-benzoyl)-thiophene-2-sulfonyl chloride

4-(4-Methoxybenzoyl)thiophene-2-sulfonamide

4-<3-<(dimethylamino)methyl>-4-hydroxybenzoyl>thiophene-2-sulfonamide

Refernces

• 1、 Kim, Hyunseok,Park, Sangjune,Baek, Yonghyeon,Um, Kyusik,Han, Gi Uk,Jeon, Da-Hye,Han, Sang Hoon,Lee, Phil Ho. "Synthesis of diaryl ketones through oxidative cleavage of the C-C double bonds in N -Sulfonyl enamides". . p. 3486 - 3496. Retrieved 2018/04/14.
• 2、 Chen, Qiang,Fan, Xin-Heng,Zhang, Li-Peng,Yang, Lian-Ming. "Nickel-catalyzed cross-coupling of carboxylic anhydrides with arylboronic acids". . p. 53885 - 53890. Retrieved 2015/01/16.