6-ACETYL-2-AMINO-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 6-ACETYL-2-AMINO-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 24237-43-2
• Molecular Formula: C₁₂H₁₆N₂O₃S
• Molecular Weight: 268.337
• Hs Code.: 2934999090
• Mol file: 24237-43-2.mol

Synonyms:2-Amino-3-ethoxycarbonyl-6-acetyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine;ethyl 6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate;6-Acetyl-2-amino-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester;

Chemical Property of 6-ACETYL-2-AMINO-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 7.94E-11mmHg at 25°C
• Refractive Index: 1.601
• Boiling Point: 517.8 °C at 760 mmHg
• PKA: 0.16±0.20(Predicted)
• Flash Point: 267 °C
• PSA: 100.87000
• Density: 1.31 g/cm³
• LogP: 1.93070
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 6-acetyl-2-amino-4,5,6,7-tetrahydrothieno-[2,3-c]pyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-ACETYL-2-AMINO-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER

There total 2 articles about 6-ACETYL-2-AMINO-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-acetyl-4-piperidinone (32161-06-1) + ethyl 2-cyanoacetate (105-56-6) → ethyl 6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (24237-43-2)

Guidance literature:

With sulfur; triethylamine; In ethanol; at 70 ℃; for 2h; Inert atmosphere;

DOI:10.3390/molecules25071690

Reference yield:

→ ethyl 6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (24237-43-2)

Guidance literature:

entspr.4-Piperidon, S, NCCH2CO2Et;

Reference yield: 59.0%

ethyl 6-acetyl-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (24237-43-2) → 6-acetyl-2-amino-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid (487413-70-7) + 2-amino-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid (37636-42-3)

Guidance literature:

With sodium hydroxide; In methanol; at 0 - 20 ℃;

DOI:10.1016/S0960-894X(02)00332-3

upstream raw materials:

1-acetyl-4-piperidinone

ethyl 2-cyanoacetate

Downstream raw materials:

6-acetyl-2-amino-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid

2-amino-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid

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