Carbamic acid, [3-[[(1R)-2-[4-[1-(aminomethyl)cyclohexyl]-1-piperazinyl]-1-[(2,4-dichloro phenyl)methyl]-2-oxoethyl]amino]-3-oxopropyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [3-[[(1R)-2-[4-[1-(aminomethyl)cyclohexyl]-1-piperazinyl]-1-[(2,4-dichloro phenyl)methyl]-2-oxoethyl]amino]-3-oxopropyl]-, 1,1-dimethylethyl ester
CAS No.:511540-36-6
Molecular Formula:C₂₈H₄₃Cl₂N₅O₄
Molecular Weight:584.587
Hs Code.:

Carbamic acid,
[3-[[(1R)-2-[4-[1-(aminomethyl)cyclohexyl]-1-piperazinyl]-1-[(2,4-dichloro
phenyl)methyl]-2-oxoethyl]amino]-3-oxopropyl]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [3-[[(1R)-2-[4-[1-(aminomethyl)cyclohexyl]-1-piperazinyl]-1-[(2,4-dichloro phenyl)methyl]-2-oxoethyl]amino]-3-oxopropyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [3-[[(1R)-2-[4-[1-(aminomethyl)cyclohexyl]-1-piperazinyl]-1-[(2,4-dichloro phenyl)methyl]-2-oxoethyl]amino]-3-oxopropyl]-, 1,1-dimethylethyl ester

There total 5 articles about Carbamic acid, [3-[[(1R)-2-[4-[1-(aminomethyl)cyclohexyl]-1-piperazinyl]-1-[(2,4-dichloro phenyl)methyl]-2-oxoethyl]amino]-3-oxopropyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 139754-93-1
1-(4-benzylpiperazin-1-yl)cyclohexanecarbonitrile

: 511540-36-6
{2-[2-[4-(1-aminomethyl-cyclohexyl)-piperazin-1-yl]-1-(2,4-dichloro-benzyl)-2-oxo-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / LiAlH₄ / diethyl ether / 0.5 h / 20 °C

2: 100 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

3: 86 percent / NH₄COOH / Pd/C / methanol / 2 h / 65 °C

4: 54 percent / HBTU; EtN(iPr)2 / dimethylformamide / 8 h / 20 °C

5: 86 percent / aq. K₂CO₃ / methanol / 8 h / 65 °C

With lithium aluminium tetrahydride; ammonium formate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.017

Reference yield:

: 511538-96-8
(1-(4-benzylpiperazin-1-yl)cyclohexyl)methanamine

: 511540-36-6
{2-[2-[4-(1-aminomethyl-cyclohexyl)-piperazin-1-yl]-1-(2,4-dichloro-benzyl)-2-oxo-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 86 percent / NH₄COOH / Pd/C / methanol / 2 h / 65 °C

3: 54 percent / HBTU; EtN(iPr)2 / dimethylformamide / 8 h / 20 °C

4: 86 percent / aq. K₂CO₃ / methanol / 8 h / 65 °C

With ammonium formate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.017

Reference yield:

: 511540-35-5
N-((1-(4-benzylpiperazin-1-yl)cyclohexyl)methyl)-2,2,2-trifluoroacetamide

: 511540-36-6
{2-[2-[4-(1-aminomethyl-cyclohexyl)-piperazin-1-yl]-1-(2,4-dichloro-benzyl)-2-oxo-ethylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / NH₄COOH / Pd/C / methanol / 2 h / 65 °C

2: 54 percent / HBTU; EtN(iPr)2 / dimethylformamide / 8 h / 20 °C

3: 86 percent / aq. K₂CO₃ / methanol / 8 h / 65 °C

With ammonium formate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.05.017