Carbamic acid, [[3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-1-piperidinyl]iminometh yl]-, phenylmethyl ester, (S)-

Base Information

• Chemical Name: Carbamic acid, [[3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-1-piperidinyl]iminometh yl]-, phenylmethyl ester, (S)-
• CAS No.: 51219-20-6
• Molecular Formula: C19H26N4O5
• Molecular Weight: 390.43400
• Mol file: 51219-20-6.mol

Synonyms:

Chemical Property of Carbamic acid, [[3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-1-piperidinyl]iminometh yl]-, phenylmethyl ester, (S)-

Chemical Property:

• Melting Point: 164-166 °C
• PSA: 118.12000
• Density: 1.27±0.1 g/cm3(Predicted)
• LogP: 2.61830

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [[3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-1-piperidinyl]iminometh yl]-, phenylmethyl ester, (S)-

There total 9 articles about Carbamic acid, [[3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-oxo-1-piperidinyl]iminometh yl]-, phenylmethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

N7-<(benzyloxy)carbonyl>-N2-<(tert-butoxy)carbonyl>-L-arginine (51219-18-2) → [(3S)-1-(benzyloxycarbonylamino-imino-methyl)-2-oxo-piperidin-3-yl]-carbamic acid tert-butyl ester (51219-20-6)

Guidance literature:

With benzyl chloroformate; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(99)00130-4

Reference yield:

L-arginine (74-79-3,25212-18-4) + di-tert-butyl dicarbonate (24424-99-5) + benzyl chloroformate (501-53-1,94274-21-2) → [(3S)-1-(benzyloxycarbonylamino-imino-methyl)-2-oxo-piperidin-3-yl]-carbamic acid tert-butyl ester (51219-20-6)

Guidance literature:

L-arginine; di-tert-butyl dicarbonate; With sodium hydroxide; In water; tert-butyl alcohol; at 15 - 25 ℃;

benzyl chloroformate; With potassium hydroxide; In methanol; tert-butyl alcohol; at 20 ℃; for 5h;

With triethylamine; isobutyl chloroformate; In tetrahydrofuran; methanol; water; tert-butyl alcohol; at 0 - 10 ℃;

Reference yield:

C24H36N4O8 → Boc-Arg(Z)> (51219-20-6)

Guidance literature:

With triethylamine; Yield given;

DOI:10.1021/jm00168a030

upstream raw materials:

N⁷-<(benzyloxy)carbonyl>-N²-<(tert-butoxy)carbonyl>-L-arginine

N^α-t-butoxycarbonyl-arginine hydrochloride

benzyl chloroformate

L-arginine

Downstream raw materials:

C₂₆H₃₁N₅O₅S

C₂₁H₂₃N₅O₃S