[1,4'-Bipiperidine]-1'-propanamide, b-oxo-a-[(3S,4R)-2-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]-4-[(1E)- 2-phenylethenyl]-1-azetidinyl]-N-[[3-(trifluoromethyl)phenyl]methyl]-

Base Information

Chemical Name:[1,4'-Bipiperidine]-1'-propanamide, b-oxo-a-[(3S,4R)-2-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]-4-[(1E)- 2-phenylethenyl]-1-azetidinyl]-N-[[3-(trifluoromethyl)phenyl]methyl]-
CAS No.:512784-11-1
Molecular Formula:C41H44F3N5O5
Molecular Weight:743.826
Hs Code.:

[1,4'-Bipiperidine]-1'-propanamide,
b-oxo-a-[(3S,4R)-2-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]-4-[(1E)-
2-phenylethenyl]-1-azetidinyl]-N-[[3-(trifluoromethyl)phenyl]methyl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [1,4'-Bipiperidine]-1'-propanamide, b-oxo-a-[(3S,4R)-2-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]-4-[(1E)- 2-phenylethenyl]-1-azetidinyl]-N-[[3-(trifluoromethyl)phenyl]methyl]-

Chemical Property:

Purity/Quality:

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Technology Process of [1,4'-Bipiperidine]-1'-propanamide, b-oxo-a-[(3S,4R)-2-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]-4-[(1E)- 2-phenylethenyl]-1-azetidinyl]-N-[[3-(trifluoromethyl)phenyl]methyl]-

There total 9 articles about [1,4'-Bipiperidine]-1'-propanamide, b-oxo-a-[(3S,4R)-2-oxo-3-[(4S)-2-oxo-4-phenyl-3-oxazolidinyl]-4-[(1E)- 2-phenylethenyl]-1-azetidinyl]-N-[[3-(trifluoromethyl)phenyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 512784-02-0
2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-malonamic acid

: 4897-50-1
4-piperidinopiperidin

: 512784-11-1
3-[1,4']bipiperidinyl-1'-yl-3-oxo-2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-propionamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: (3-phenyl-allylideneamino)-acetic acid tert-butyl ester

: 512784-11-1
3-[1,4']bipiperidinyl-1'-yl-3-oxo-2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 5.5 g / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

2.2: 56 percent / tetrahydrofuran

3.1: 82 percent / tetrahydrofuran / Heating

4.1: 100 percent / formic acid / 20 °C

5.1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; HOAt / CH₂Cl₂ / 20 °C

With formic acid; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1.1: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031

Reference yield:

: 14371-10-9
(E)-3-phenylpropenal

: 512784-11-1
3-[1,4']bipiperidinyl-1'-yl-3-oxo-2-[2-oxo-3-(2-oxo-4-phenyl-oxazolidin-3-yl)-4-styryl-azetidin-1-yl]-N-(3-trifluoromethyl-benzyl)-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: desiccating agent / CH₂Cl₂ / 20 °C

2.1: 5.5 g / amine / CH₂Cl₂ / 1 h / 0 - 20 °C

3.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

3.2: 56 percent / tetrahydrofuran

4.1: 82 percent / tetrahydrofuran / Heating

5.1: 100 percent / formic acid / 20 °C

6.1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; HOAt / CH₂Cl₂ / 20 °C

With formic acid; 1-hydroxy-7-aza-benzotriazole; desiccating agent; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 2.1: Staudinger cycloaddition;
DOI:10.1016/j.bmc.2006.12.031