Technology Process of 9-(hydroxymethyl)-6,6-dimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
There total 11 articles about 9-(hydroxymethyl)-6,6-dimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 3h;
Ambient temperature;
DOI:10.1139/v82-403
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 24 percent / water, stannic chloride / CH2Cl2 / 7 h / 0 °C
2: 58 percent / aluminium chloride / CH2Cl2 / 5 h / Ambient temperature
3: 1) benzyltriethylammonium chloride, aq. sodium hydroxide; 2) magnesium bromide / 1) acetonitrile, 2 h; 2) THF, 2 d, r.t.
4: 90 percent / lithium carbonate, lithium bromide (0.50 mmol) / dimethylformamide / 6 h / 100 °C
5: 88 percent / lithium aluminium hydride / tetrahydrofuran / 3 h / Ambient temperature
With
sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; N-benzyl-N,N,N-triethylammonium chloride; water; tin(IV) chloride; lithium carbonate; lithium bromide; magnesium bromide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1139/v82-403
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 58 percent / aluminium chloride / CH2Cl2 / 5 h / Ambient temperature
2: 1) benzyltriethylammonium chloride, aq. sodium hydroxide; 2) magnesium bromide / 1) acetonitrile, 2 h; 2) THF, 2 d, r.t.
3: 90 percent / lithium carbonate, lithium bromide (0.50 mmol) / dimethylformamide / 6 h / 100 °C
4: 88 percent / lithium aluminium hydride / tetrahydrofuran / 3 h / Ambient temperature
With
sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; N-benzyl-N,N,N-triethylammonium chloride; lithium carbonate; lithium bromide; magnesium bromide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1139/v82-403