2-Chloro-4-aMino-benzeneMethanol

Base Information

• Chemical Name: 2-Chloro-4-aMino-benzeneMethanol
• CAS No.: 51420-25-8
• Molecular Formula: C7H8ClNO
• Molecular Weight: 157.6
• Mol file: 51420-25-8.mol

Synonyms:2-Chloro-4-amino-benzenemethanol;Benzenemethanol,4-amino-2-chloro;

Chemical Property of 2-Chloro-4-aMino-benzeneMethanol

Chemical Property:

• Boiling Point: 323.8±27.0 °C(Predicted)
• PKA: 13.85±0.10(Predicted)
• PSA: 46.25000
• Density: 1.341±0.06 g/cm3(Predicted)
• LogP: 1.99570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

95% ^*data from raw suppliers

(4-amino-2-chlorophenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-aMino-benzeneMethanol

There total 5 articles about 2-Chloro-4-aMino-benzeneMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl 4-amino-2-chlorobenzoate (46004-37-9) → 4-amino-2-chloro-benzyl alcohol (51420-25-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

Reference yield: 56.0%

4-amino-2-chlorobenzoic acid (2457-76-3) → 4-amino-2-chloro-benzyl alcohol (51420-25-8)

Guidance literature:

4-amino-2-chlorobenzoic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Heating / reflux;

With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 1h;

Reference yield:

(2-chloro-4-nitrophenyl)methanol (52301-88-9) → 4-amino-2-chloro-benzyl alcohol (51420-25-8)

Guidance literature:

With hydrogenchloride; at 100 ℃;

upstream raw materials:

(2-chloro-4-nitrophenyl)methanol

4-amino-2-chlorobenzoic acid

methyl 4-amino-2-chlorobenzoate

Downstream raw materials:

4-amino-2-chloro-benzaldehyde

N-(3-chloro-4-hydroxymethylphenyl)carbamic acid t-butyl ester

N-(3-chloro-4-hydroxymethyl-phenyl)-2-(2-chloro-4-trifluoromethyl-phenoxy)-acetamide

(4-chloro-2-nitrophenyl)methanol

Refernces

• 1、 -. "Pyrazolothiazole Protein Kinase Modulators". Page/Page column 52. . Retrieved 2010/11/27.