OXOLINIC ACID SODIUM SALT

Base Information

• Chemical Name: OXOLINIC ACID SODIUM SALT
• CAS No.: 59587-08-5
• Molecular Formula: C13H11 N O5 . Na
• Molecular Weight: 283.216
• Mol file: 59587-08-5.mol

Synonyms:1,3-Dioxolo[4,5-g]quinoline-7-carboxylicacid, 5-ethyl-5,8-dihydro-8-oxo-, sodium salt (9CI); Oxolinic acid sodium salt;Sodium 1-ethyl-6,7-methylenedioxy-4-quinolone-3-carboxylate; Sodium oxolinate

Chemical Property of OXOLINIC ACID SODIUM SALT

Chemical Property:

• Vapor Pressure: 9.24E-10mmHg at 25°C
• Boiling Point: 473.2°C at 760 mmHg
• Flash Point: 240°C
• PSA: 80.59000
• LogP: 0.11360

Purity/Quality:

99% ^*data from raw suppliers

SODIUM OXOLINATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: Oxolinic acid sodium salt is a chemical compound with various applications across different fields. In the field of medicine and veterinary science, it is utilized as an antibiotic, specifically for the treatment of bacterial infections in both humans and animals. Its role is crucial in combating bacterial pathogens, particularly those causing urinary tract infections and respiratory tract infections. In the aquaculture and fish farming industry, oxolinic acid sodium salt may be used to treat bacterial infections in fish, promoting healthier and disease-free aquatic environments. Additionally, in the research field, it can serve as a reference standard for analytical chemistry techniques like high-performance liquid chromatography (HPLC), aiding in the accurate detection and quantification of antibiotics in pharmaceuticals and biological samples. Its versatility as an antibiotic, particularly in medicine and aquaculture, underscores its significance in treating bacterial infections and maintaining the health of humans, animals, and aquatic ecosystems, while also being a useful tool in analytical chemistry.

Technology Process of OXOLINIC ACID SODIUM SALT

There total 1 articles about OXOLINIC ACID SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxolinic Acid (14698-29-4) → oxolinic acid sodium salt (59587-08-5)

Guidance literature:

With sodium hydroxide; In water; N,N-dimethyl-formamide;

Reference yield: 65.0%

oxolinic acid sodium salt (59587-08-5) + 2-Chloromethoxy-1-isopropyl-4-methyl-benzene (135922-44-0) → 5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 2-isopropyl-5-methyl-phenoxymethyl ester (135922-47-3)

Guidance literature:

With Aliquat 336; In dichloromethane; water; for 1h; Ambient temperature;

DOI:10.1016/0223-5234(91)90108-Y

Reference yield: 59.7%

(6R-trans)-3-(iodomethyl)-8-oxo-7-<(phenoxyacetyl)amino>-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid tert-butyl ester (115622-66-7) + oxolinic acid sodium salt (59587-08-5) → 5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid (6R,7R)-2-tert-butoxycarbonyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl ester (115622-65-6)

Guidance literature:

In N,N-dimethyl-formamide; for 6h;

DOI:10.1021/jm00163a013

upstream raw materials:

oxolinic Acid

Downstream raw materials:

5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 2-methoxy-phenoxymethyl ester

5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid (6R,7R)-2-tert-butoxycarbonyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl ester

5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid (6R,7R)-2-tert-butoxycarbonyl-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl ester

5-Ethyl-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid 4-formyl-phenoxymethyl ester

Refernces