2-(4-BroMo-phenyl)-3-Methyl-butyric acid

Base Information

• Chemical Name: 2-(4-BroMo-phenyl)-3-Methyl-butyric acid
• CAS No.: 51632-30-5
• Molecular Formula: C11H13BrO2
• Molecular Weight: 257.127
• Mol file: 51632-30-5.mol

Synonyms:4-Bromo-α-iso-propyl phenylacetic acid;2-(4-bromophenyl)-3-methylbutyric acid;2-(4-BROMO-PHENYL)-3-METHYL-BUTYRIC ACID;4-Bromo-α-isopropyl-phenylacetic acid;α-Isopropyl-4-bromphenyl-essigsaeure;

Chemical Property of 2-(4-BroMo-phenyl)-3-Methyl-butyric acid

Chemical Property:

• PSA: 37.30000
• LogP: 3.27330

Purity/Quality:

2-(4-Bromophenyl)-3-methylbutanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-BroMo-phenyl)-3-Methyl-butyric acid

There total 4 articles about 2-(4-BroMo-phenyl)-3-Methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(4-bromophenyl)-3-methylbutanoate (1282659-85-1) → (+/-)-2-(4-bromophenyl)-3-methylbutanoic acid (51632-30-5)

Guidance literature:

ethyl 2-(4-bromophenyl)-3-methylbutanoate; With water; potassium hydroxide; In ethylene glycol; at 150 ℃; for 16h;

With hydrogenchloride; In water; ethylene glycol; at 20 ℃;

Reference yield:

2-(4-bromophenyl)-3-methylbutyronitrile (51632-12-3) → (+/-)-2-(4-bromophenyl)-3-methylbutanoic acid (51632-30-5)

Guidance literature:

With sulfuric acid;

Reference yield:

Ethyl 4-bromophenylacetate (14062-25-0) → (+/-)-2-(4-bromophenyl)-3-methylbutanoic acid (51632-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / -78 °C

1.2: -78 - 20 °C

2.1: potassium hydroxide; water / ethylene glycol / 16 h / 150 °C

2.2: 20 °C

With water; sodium hydride; potassium hydroxide; In ethylene glycol; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

2-(4-bromophenyl)-3-methylbutyronitrile

Ethyl 4-bromophenylacetate

ethyl 2-(4-bromophenyl)-3-methylbutanoate

Refernces

• 1、 -. "BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION". . . Retrieved 2012/06/30.
• 2、 -. "Insecticidal esters of substituted furan methanol". . . Retrieved 2008/06/13.