Technology Process of Phenol, 4-[4-(2-aminoethyl)phenoxy]-, hydrochloride
There total 7 articles about Phenol, 4-[4-(2-aminoethyl)phenoxy]-, hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethyl acetate;
at 20 ℃;
DOI:10.1021/jm0505718
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / aq. NaHCO3 / tetrahydrofuran / 24 h
2: 40 percent / Cu(OAc)2; Et3N; pyridine / 4 Angstroem molecular sieves / CH2Cl2 / 20 °C
3: 86 percent / TBAF / tetrahydrofuran / 0 °C
4: 100 percent / HCl / ethyl acetate / 20 °C
With
pyridine; hydrogenchloride; copper diacetate; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; triethylamine;
4 A molecular sieve;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm0505718
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 82 percent / imidazole / CH2Cl2 / 12.5 h / 0 - 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: triisopropyl borate / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
2.3: 68 percent / aq. HCl / tetrahydrofuran; hexane / 0.5 h / 0 °C
3.1: 40 percent / Cu(OAc)2; Et3N; pyridine / 4 Angstroem molecular sieves / CH2Cl2 / 20 °C
4.1: 86 percent / TBAF / tetrahydrofuran / 0 °C
5.1: 100 percent / HCl / ethyl acetate / 20 °C
With
pyridine; 1H-imidazole; hydrogenchloride; n-butyllithium; copper diacetate; tetrabutyl ammonium fluoride; triethylamine;
4 A molecular sieve;
In
tetrahydrofuran; hexane; dichloromethane; ethyl acetate;
DOI:10.1021/jm0505718
