1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO

Base Information

Chemical Name:1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO
CAS No.:52377-28-3
Molecular Formula:C₁₂H₁₁ClN₂O₂
Molecular Weight:250.685
Hs Code.:2933990090
Mol file:52377-28-3.mol

Synonyms:1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO;nalidixoyl chloride;

Suppliers and Price of 1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carbonyl chloride 97%
1g
$ 623.00

Labseeker
1,8-NAPHTHYRIDINE-3-CARBONYLCHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO 95
5g
$ 1333.00

Atlantic Research Chemicals
1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carbonylchloride 95%
1gm:
$ 279.23

Atlantic Research Chemicals
1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carbonylchloride 95%
250mgs:
$ 137.85

American Custom Chemicals Corporation
1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO 95.00%
5MG
$ 501.55

Total 5 raw suppliers

Chemical Property of 1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO

Chemical Property:

PSA：51.96000
LogP:2.10380

Purity/Quality:

99%, ^*data from raw suppliers

1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carbonyl chloride 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO

There total 2 articles about 1,8-NAPHTHYRIDINE-3-CARBONYL CHLORIDE,1-ETHYL-1,4-DIHYDRO-7-METHYL-4-OXO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 389-08-2
nalidixic Acid

: 52377-28-3
nalidixic acid chloride

Guidance literature:: With thionyl chloride; In chloroform; at 25 - 30 ℃; for 4h;

Reference yield:

: 33331-59-8
ethyl 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

: 52377-28-3
nalidixic acid chloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 20 °C

2: triethylamine; thionyl chloride / 20 °C

With thionyl chloride; triethylamine; sodium hydroxide; In ethanol;
DOI:10.1007/s11224-022-01889-0

Reference yield:

: 52377-28-3
nalidixic acid chloride

: 536-74-3
phenylacetylene

: 1352786-64-1
1-ethyl-7-methyl-3-(3-phenylprop-2-ynoyl)-1,4-dihydro-1,8-naphthyridin-4-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In 1,4-dioxane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/anie.201103296