4-(2-CHLORO-ETHYL)-1H-IMIDAZOLE HCL

Base Information

• Chemical Name: 4-(2-CHLORO-ETHYL)-1H-IMIDAZOLE HCL
• CAS No.: 6429-10-3
• Molecular Formula: C5H8Cl2N2
• Molecular Weight: 167.038
• Hs Code.: 2933290090
• Mol file: 6429-10-3.mol

Synonyms:1H-Imidazole,4-(2-chloroethyl)-, monohydrochloride (9CI);Imidazole, 4-(2-chloroethyl)-,monohydrochloride (8CI);4-(2-Chloroethyl)-1H-imidazole hydrochloride;4-(2-Chloroethyl)imidazole hydrochloride;

Chemical Property of 4-(2-CHLORO-ETHYL)-1H-IMIDAZOLE HCL

Chemical Property:

• Vapor Pressure: 3.92E-05mmHg at 25°C
• Boiling Point: 347 °C at 760 mmHg
• Flash Point: 163.7 °C
• PSA: 28.68000
• LogP: 1.99300
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-(2-chloroethyl)-1H-imidazolehydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-CHLORO-ETHYL)-1H-IMIDAZOLE HCL

There total 3 articles about 4-(2-CHLORO-ETHYL)-1H-IMIDAZOLE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

histamine dichloride (56-92-8) → 4-(2-chloroethyl)-1H-imidazole hydrochloride (6429-10-3)

Guidance literature:

histamine dichloride; With hydrogenchloride; sodium nitrite; at 60 ℃; for 1h;

With thionyl chloride; for 0.5h; Reflux;

DOI:10.1248/cpb.58.1552

Reference yield:

histamine dichloride (56-92-8) → 4-(2-chloroethyl)-1H-imidazole hydrochloride (6429-10-3) + 4-(2-bromoethyl)-1H-imidazole hydrochloride (791634-10-1)

Guidance literature:

With sulfuric acid; potassium bromide; sodium nitrite; at -15 - 20 ℃; for 3h; Title compound not separated from byproducts;

DOI:10.1021/ja046964y

Reference yield:

→ 4-(2-chloroethyl)-1H-imidazole hydrochloride (6429-10-3)

Guidance literature:

4-Imidazolethanol, 1) HCl, 2) SOCl2;

upstream raw materials:

histamine dichloride

Downstream raw materials:

N-methyl-2-(1H-imidazol-4-yl)ethanamine

4-(2-Chloro-ethyl)-1-(toluene-4-sulfonyl)-1H-imidazole

tert-butyl (2-(1H-imidazol-4-yl)ethyl)(benzyloxy)carbamate

Refernces

• 1、 Takeuchi, Yasuo,Ozaki, Satoru,Satoh, Masahiro,Mimura, Ken-Ichiro,Hara, Sei-Ichi,Abe, Hitoshi,Nishioka, Hiromi,Harayama, Takashi. "Synthesis of acinetobactin". scheme or table. p. 1552 - 1553. Retrieved 2010/12/24.