ALPHA-METHYL-M-METHOXY-DL-PHENYLALANINE

Base Information

• Chemical Name: ALPHA-METHYL-M-METHOXY-DL-PHENYLALANINE
• CAS No.: 2349-31-7
• Molecular Formula: C11H15 N O3
• Molecular Weight: 209.245
• Hs Code.: 2922509090
• Mol file: 2349-31-7.mol

Synonyms:DL-Phenylalanine,3-methoxy-a-methyl-; (?à)-2-Amino-3-(3-methoxyphenyl)-2-methylpropionicacid; DL-a-Methyl-m-methoxyphenylalanine;NSC 92524; a-Methyl-DL-m-methoxyphenylalanine

Chemical Property of ALPHA-METHYL-M-METHOXY-DL-PHENYLALANINE

Chemical Property:

• Vapor Pressure: 1.2E-05mmHg at 25°C
• Boiling Point: 354.8°Cat760mmHg
• Flash Point: 168.4°C
• PSA: 72.55000
• Density: 1.178g/cm³
• LogP: 1.74000
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

ALPHA-METHYL-M-METHOXY-DL-PHENYLALANINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ALPHA-METHYL-M-METHOXY-DL-PHENYLALANINE

There total 5 articles about ALPHA-METHYL-M-METHOXY-DL-PHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-amino-3-(3-methoxy-phenyl)-2-methyl-propionic acid (2349-31-7)

Guidance literature:

With barium dihydroxide; water;

DOI:10.1021/ja01608a046

Reference yield:

5-(3-methoxy-benzyl)-5-methyl-imidazolidine-2,4-dione (39896-39-4) → 2-amino-3-(3-methoxy-phenyl)-2-methyl-propionic acid (2349-31-7)

Guidance literature:

With barium dihydroxide;

DOI:10.1021/jm00281a021

Reference yield:

m-methoxybenzyl chloride (824-98-6) → 2-amino-3-(3-methoxy-phenyl)-2-methyl-propionic acid (2349-31-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NaI / acetone / 12 h

2: 1) LiN(SiMe₃)2 / 1) THF, -76 deg C, 20 min, 2) -76 deg C to RT, overnight

3: HOAc, conc. aq. HCl / 2 h / Heating

With hydrogenchloride; acetic acid; sodium iodide; lithium hexamethyldisilazane; In acetone;

upstream raw materials:

5-(3-methoxy-benzyl)-5-methyl-imidazolidine-2,4-dione

3-methoxybenzyl iodide

m-methoxybenzyl chloride

Downstream raw materials:

rac-3-(3-Methoxyphenyl)-2-methyl-alanin-methylester

α-methyl-m-DL-tyrosine

Refernces