(R)-2-Phenyl-2-pentanol

Base Information

• Chemical Name: (R)-2-Phenyl-2-pentanol
• CAS No.: 52992-90-2
• Molecular Formula: C11H16O
• Molecular Weight: 164.247
• DSSTox Substance ID: DTXSID501288002
• Nikkaji Number: J703.141F
• Mol file: 52992-90-2.mol

Synonyms:(R)-2-Phenyl-2-pentanol;DTXSID501288002;(alphaR)-alpha-Methyl-alpha-propylbenzenemethanol;52992-90-2

Chemical Property of (R)-2-Phenyl-2-pentanol

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 164.120115130
• Heavy Atom Count: 12
• Complexity: 127

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC(C)(C1=CC=CC=C1)O
• Isomeric SMILES: CCC[C@](C)(C1=CC=CC=C1)O

Technology Process of (R)-2-Phenyl-2-pentanol

There total 11 articles about (R)-2-Phenyl-2-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

phenylmagnesium bromide (1589-82-8) + propionaldehyde (123-38-6) → 1-phenyl-2-butanol (701-70-2) + (R)-2-phenyl-2-pentanol (52992-90-2)

Guidance literature:

With (5aS,10aS)-(-)-Octahydro-5H,10H-dipyrrolo<1,2-a:1',2'-d>pyrazin; In tetrahydrofuran; toluene; at -100 ℃; for 5h; Yields of byproduct given. Title compound not separated from byproducts;

Reference yield:

(+/-)-2-phenylpent-2-yl hydroperoxide (139470-88-5,139470-92-1) → C11H16O2 + C11H16O2 + (S)-2-phenyl-2-pentanol (52992-91-3) + (R)-2-phenyl-2-pentanol (52992-90-2)

Guidance literature:

With (Sp)-xylyl-PHANEPHOS; In chloroform-d1; at -67 - 25 ℃; Title compound not separated from byproducts.;

DOI:10.1021/ja070482f

Reference yield:

(SS)-1-(N-methylphenylsulfonimidoyl)-2-phenyl-2-propanol (80441-27-6) → 2-Phenyl-pentan-2-ol (52992-90-2)

Guidance literature:

With Raney nickel W-2; In diethyl ether; water; Ambient temperature;

DOI:10.1021/jo00346a010

upstream raw materials:

(SS)-1-(N-methylphenylsulfonimidoyl)-2-phenyl-2-propanol

propiophenone

phthalic anhydride

phenylmagnesium bromide

Downstream raw materials:

D-2-phenyl-pentane