2(1H)-Quinolinone, 5-[(1R)-2-[[2-(4-bromophenyl)ethyl]amino]-1-[[(1,1-dimethylethyl)dimeth ylsilyl]oxy]ethyl]-8-(phenylmethoxy)-, monohydrochloride

Base Information

Chemical Name:2(1H)-Quinolinone, 5-[(1R)-2-[[2-(4-bromophenyl)ethyl]amino]-1-[[(1,1-dimethylethyl)dimeth ylsilyl]oxy]ethyl]-8-(phenylmethoxy)-, monohydrochloride
CAS No.:530084-80-1
Molecular Formula:C32H39BrN2O3Si.ClH
Molecular Weight:644.124
Hs Code.:

2(1H)-Quinolinone,
5-[(1R)-2-[[2-(4-bromophenyl)ethyl]amino]-1-[[(1,1-dimethylethyl)dimeth
ylsilyl]oxy]ethyl]-8-(phenylmethoxy)-, monohydrochloride

Synonyms:

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Chemical Property of 2(1H)-Quinolinone, 5-[(1R)-2-[[2-(4-bromophenyl)ethyl]amino]-1-[[(1,1-dimethylethyl)dimeth ylsilyl]oxy]ethyl]-8-(phenylmethoxy)-, monohydrochloride

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2(1H)-Quinolinone, 5-[(1R)-2-[[2-(4-bromophenyl)ethyl]amino]-1-[[(1,1-dimethylethyl)dimeth ylsilyl]oxy]ethyl]-8-(phenylmethoxy)-, monohydrochloride

There total 1 articles about 2(1H)-Quinolinone, 5-[(1R)-2-[[2-(4-bromophenyl)ethyl]amino]-1-[[(1,1-dimethylethyl)dimeth ylsilyl]oxy]ethyl]-8-(phenylmethoxy)-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 530084-74-3
(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one

: 73918-56-6
4-Bromophenethylamine

: 530084-80-1
8-benzyloxy-5-[(R)-2-[2-(4-bromo-phenyl)-ethylamino]-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-quinolin-2-one hydrochloride

Guidance literature:: (R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one; 4-Bromophenethylamine; In dimethyl sulfoxide; at 85 ℃; for 5h;

With sodium hydroxide; In water; dimethyl sulfoxide; ethyl acetate;

With hydrogenchloride; In cyclohexane; water; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; for 5h;

Reference yield: 65.0%

: 530084-80-1
8-benzyloxy-5-[(R)-2-[2-(4-bromo-phenyl)-ethylamino]-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-quinolin-2-one hydrochloride

: {4-[(2-amino-2-methylpropyl)oxy]phenyl}amine dihydrochloride

: 860032-33-3
5-[(R)-2-(2-{4-[4-(2-amino-2-methyl-propoxy)-phenylamino]-phenyl}-ethylamino)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-8-benzyloxy-1H-quinolin-2-one

Guidance literature:: 8-benzyloxy-5-[(R)-2-[2-(4-bromo-phenyl)-ethylamino]-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-quinolin-2-one hydrochloride; {4-[(2-amino-2-methylpropyl)oxy]phenyl}amine dihydrochloride; With sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; at 84 - 90 ℃; for 4h;

With hydrogenchloride; In 1,4-dioxane; methanol; acetic acid methyl ester; water; at 47 - 53 ℃; for 17h;

With sodium hydroxide; In 1,4-dioxane; methanol; acetic acid methyl ester; water; at 17 - 23 ℃; Product distribution / selectivity;

Reference yield:

: 530084-80-1
8-benzyloxy-5-[(R)-2-[2-(4-bromo-phenyl)-ethylamino]-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-quinolin-2-one hydrochloride

: 92028-21-2
4-methoxy-3-phenylaniline hydrochloride

: 530084-77-6
N-{2-[4-(3-phenyl-4-methoxyphenyl)aminophenyl]ethyl}-(R)-2-tert-butyldimethylsilyl-2-(8-benzyloxy-2(1H)-quinolinon-5-yl)ethylamine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 85 - 89 ℃; for 2.5h;