N-(4-(4-Amino-2-ethyl-imidazo(4,5-c)quinolin-1-yl)butyl)methanesulfonamide

Base Information

Chemical Name:N-(4-(4-Amino-2-ethyl-imidazo(4,5-c)quinolin-1-yl)butyl)methanesulfonamide
CAS No.:532959-63-0
Molecular Formula:C17H23N5O2S
Molecular Weight:361.468
Hs Code.:
UNII:6PJC3KPK6S
DSSTox Substance ID:DTXSID20201416
Wikidata:Q27074039
NCI Thesaurus Code:C61104
Pharos Ligand ID:6Y1SCTDW673G
Metabolomics Workbench ID:153460
ChEMBL ID:CHEMBL549344
Mol file:532959-63-0.mol

Synonyms:852A compound;N-(4-(4-amino-2-ethyl-1H-imidazo(4,5-c)quinolin-1-yl)butyl)methanesulfonamide;N-(4-(4-amino-2-ethyl-1H-imidazo(4,5c)quinolin-1-yl)butyl)methanesulfonamide;PF-04878691;S 32865;S-32865;S32865;toll-like receptor 7 agonist 852A

Suppliers and Price of N-(4-(4-Amino-2-ethyl-imidazo(4,5-c)quinolin-1-yl)butyl)methanesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of N-(4-(4-Amino-2-ethyl-imidazo(4,5-c)quinolin-1-yl)butyl)methanesulfonamide

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:361.15724617
Heavy Atom Count:25
Complexity:538

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=NC2=C(N1CCCCNS(=O)(=O)C)C3=CC=CC=C3N=C2N
Recent ClinicalTrials:Study of Immune Response Modifier in the Treatment of Hematologic Malignancies
Recent EU Clinical Trials:Pilot Phase II, Open Label, Multicenter, Efficacy and Safety Study of 852A Administered Intravenously to Subjects with Unresectable Metastatic Cutaneous Melanoma

Technology Process of N-(4-(4-Amino-2-ethyl-imidazo(4,5-c)quinolin-1-yl)butyl)methanesulfonamide

There total 5 articles about N-(4-(4-Amino-2-ethyl-imidazo(4,5-c)quinolin-1-yl)butyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[4-(2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)-butyl]-methanesulfonamide

: 532959-63-0
N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)-butyl]-methanesulfonamide

Guidance literature:: N-[4-(2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)-butyl]-methanesulfonamide; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 6h;

With ammonia; In dichloromethane; water; at 20 ℃; for 0.25h;

With p-toluenesulfonyl chloride; In dichloromethane; water; at 20 ℃;

Reference yield:

: 960254-09-5
N-{4-[5-(2-aminophenyl)-4-cyano-2-ethyl-1H-imidazol-1-yl]butyl}methanesulfonamide

: 532959-63-0
N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)-butyl]-methanesulfonamide

Guidance literature:: N-{4-[5-(2-aminophenyl)-4-cyano-2-ethyl-1H-imidazol-1-yl]butyl}methanesulfonamide; With ethanol; acetyl chloride; for 2h; Reflux;

With sodium hydroxide; In water; at 60 ℃; pH=12;

Reference yield:

: 960254-05-1
N-[4-(5-amino-4-cyano-2-ethyl-1H-imidazol-1-yl)butyl]methanesulfonamide

: 532959-63-0
N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)-butyl]-methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diiodomethane; isopentyl nitrite / chloroform / 0.17 h / 80 °C

2.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 1 h / 90 °C / Inert atmosphere

3.1: acetyl chloride; ethanol / 2 h / Reflux

3.2: 60 °C / pH 12

With diiodomethane; ethanol; potassium carbonate; acetyl chloride; isopentyl nitrite; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; chloroform; water; 2.1: Suzuki Coupling;