alpha-Morpholino-N-phenylsuccinimide

Base Information

• Chemical Name: alpha-Morpholino-N-phenylsuccinimide
• CAS No.: 53541-45-0
• Molecular Formula: C14H16N2O3
• Molecular Weight: 260.28800
• European Community (EC) Number: 666-059-5
• Nikkaji Number: J628.396I
• Mol file: 53541-45-0.mol

Synonyms:3-morpholin-4-yl-1-phenylpyrrolidine-2,5-dione;ALPHA-MORPHOLINO-N-PHENYLSUCCINIMIDE;3-morpholino-1-phenylpyrrolidine-2,5-dione;53541-45-0;2-Morpholino-N-phenylsuccinimide;STL302280;AKOS000477643;AKOS016330827;3-(morpholin-4-yl)-1-phenylpyrrolidine-2,5-dione

Chemical Property of alpha-Morpholino-N-phenylsuccinimide

Chemical Property:

• PSA: 49.85000
• LogP: 0.65360
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 260.11609238
• Heavy Atom Count: 19
• Complexity: 360

Purity/Quality:

98%,99%, ^*data from raw suppliers

ALPHA-MORPHOLINO-N-PHENYLSUCCINIMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2CC(=O)N(C2=O)C3=CC=CC=C3

Technology Process of alpha-Morpholino-N-phenylsuccinimide

There total 4 articles about alpha-Morpholino-N-phenylsuccinimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + 5-bromo-2-furancarboxaldehyde (1899-24-7) + N-phenyl-maleimide (941-69-5) → C19H16N2O4 (1017832-06-2) + 3-(morpholin-4-yl)-1-phenylpyrrolidine-2,5-dione (53541-45-0)

Guidance literature:

morpholine; 5-bromo-2-furancarboxaldehyde; With triethylamine; In 1,4-dioxane; water; for 4h; Heating;

N-phenyl-maleimide; With magnesium sulfate; In 1,4-dioxane; water; for 24h; Further stages.; Heating;

DOI:10.1021/jo7024916

Reference yield: 49.0%

N-phenyl-maleimide (941-69-5) + (E)-3-<2-(morpholin-4-yl)vinyl>-1H-indole (133846-81-8) → 3-(morpholin-4-yl)-1-phenylpyrrolidine-2,5-dione (53541-45-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/hlca.19910740220

Reference yield:

morpholine (110-91-8,99108-56-2) + N-phenyl-maleimide (941-69-5) + bis-(diphenyl)phosphorylmethyl disulfide (1028454-98-9) → 3-(diphenyl-phosphinoylmethylsulfanyl)-1-phenylpyrrolidine-2,5-dione (1028455-04-0) + 3-(morpholin-4-yl)-1-phenylpyrrolidine-2,5-dione (53541-45-0)

Guidance literature:

morpholine; bis-(diphenyl)phosphorylmethyl disulfide; In 1,4-dioxane; at 90 ℃; for 0.5h;

N-phenyl-maleimide; In 1,4-dioxane; at 90 ℃; for 3h; Further stages.;

DOI:10.1016/j.tet.2008.02.028

upstream raw materials:

N-phenyl-maleimide

(E)-3-<2-(morpholin-4-yl)vinyl>-1H-indole

morpholine

5-bromo-2-furancarboxaldehyde

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