2-(Diphenylphosphoryl)cyclohexan-1-one

Base Information

Chemical Name:2-(Diphenylphosphoryl)cyclohexan-1-one
CAS No.:53695-49-1
Molecular Formula:C18H19O2P
Molecular Weight:298.321
Hs Code.:
DSSTox Substance ID:DTXSID10567957
Nikkaji Number:J826.854A
Mol file:53695-49-1.mol

Synonyms:53695-49-1;2-(Diphenylphosphoryl)cyclohexanone;2-(Diphenylphosphoryl)cyclohexan-1-one;(diphenylphosphoryl)cyclohexanone;DTXSID10567957

Suppliers and Price of 2-(Diphenylphosphoryl)cyclohexan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(Diphenylphosphoryl)cyclohexan-1-one

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:298.11226684
Heavy Atom Count:21
Complexity:383

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(=O)C(C1)P(=O)(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 2-(Diphenylphosphoryl)cyclohexan-1-one

There total 13 articles about 2-(Diphenylphosphoryl)cyclohexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 670-80-4
4-cyclohexen-1-ylmorpholine

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 53695-49-1
diphenyl(2-oxocyclohexyl)phosphine oxide

Guidance literature:: 4-cyclohexen-1-ylmorpholine; chloro-diphenylphosphine; With triethylamine; In acetonitrile; at 0 - 25 ℃; for 2h; Inert atmosphere;

With dimethyl sulfoxide; In acetonitrile; for 2h; Reflux;

With hydrogenchloride; In water; acetonitrile; at 0 - 25 ℃; for 12h;
DOI:10.1002/cbdv.202000217

Reference yield: 60.0%

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 53695-49-1
diphenyl(2-oxocyclohexyl)phosphine oxide

Guidance literature:: cyclohexanone; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

chloro-diphenylphosphine; In tetrahydrofuran; at -78 - 20 ℃;

With oxygen; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1039/d0cc07770d

Reference yield: 51.0%

: 670-80-4
4-cyclohexen-1-ylmorpholine

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 53695-49-1
diphenyl(2-oxocyclohexyl)phosphine oxide

: trans-2,6-bis(diphenylphosphoryl)cyclohexanone

Guidance literature:: 4-cyclohexen-1-ylmorpholine; chloro-diphenylphosphine; With triethylamine; In acetonitrile; at 0 ℃; for 3.25h; Inert atmosphere; Reflux;

With dimethyl sulfoxide; In acetonitrile; for 2h; Reflux;

With hydrogenchloride; In water; acetonitrile; at 0 - 20 ℃; for 12h; Solvent; Temperature; Time; diastereoselective reaction;
DOI:10.1055/s-0036-1588970