Acetic acid, 2,2-(1S,3S,7R,8E,11S,12S,15S,17R,21R,23R,25S)-12,25-bis(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-ene-5,13-diylidenebis-, dimethyl ester, (25Z

Base Information

Chemical Name:Acetic acid, 2,2-(1S,3S,7R,8E,11S,12S,15S,17R,21R,23R,25S)-12,25-bis(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-ene-5,13-diylidenebis-, dimethyl ester, (25Z
CAS No.:97850-05-0
Molecular Formula:C₄₁H₆₀O₁₇
Molecular Weight:824.917
Hs Code.:
Mol file:97850-05-0.mol

Acetic acid, 2,2-(1S,3S,7R,8E,11S,12S,15S,17R,21R,23R,25S)-12,25-bis(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-ene-5,13-diylidenebis-, dimethyl ester, (25Z

Synonyms:Aceticacid,2,2'-[(1S,3S,7R,8E,11S,12S,15S,17R,21R,23R,25S)-12,25-bis(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-ene-5,13-diylidene]bis-,dimethyl ester, (25Z,213E)- (9CI); Bryostatin 1,20-O-acetyl-20-O-de(1-oxo-2,4-octadienyl)-;18,27,28,29-Tetraoxatetracyclo[21.3.1.13,7.111,15]nonacosane, bryostatin 1deriv.; Acetic acid,2,2'-[12,25-bis(acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-ene-5,13-diylidene]bis-,dimethyl ester, [1S-[1R*,3R*,5Z,7S*,8E,11R*,12R*,13E,15R*,17S*(S*),21S*,23S*,25R*]]-;Bryostatin 7

Suppliers and Price of Acetic acid, 2,2-(1S,3S,7R,8E,11S,12S,15S,17R,21R,23R,25S)-12,25-bis(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-ene-5,13-diylidenebis-, dimethyl ester, (25Z

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Chemical Property of Acetic acid, 2,2-(1S,3S,7R,8E,11S,12S,15S,17R,21R,23R,25S)-12,25-bis(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-ene-5,13-diylidenebis-, dimethyl ester, (25Z

Chemical Property:

PSA：240.11000
LogP:2.38730

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Acetic acid, 2,2-(1S,3S,7R,8E,11S,12S,15S,17R,21R,23R,25S)-12,25-bis(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-ene-5,13-diylidenebis-, dimethyl ester, (25Z

There total 16 articles about Acetic acid, 2,2-(1S,3S,7R,8E,11S,12S,15S,17R,21R,23R,25S)-12,25-bis(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-ene-5,13-diylidenebis-, dimethyl ester, (25Z which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₇H₇₄O₁₇Si

: 97850-05-0
bryostatin 7

Guidance literature:: With hydrogen fluoride; In acetonitrile; Yield given;
DOI:10.1021/ja00176a058

Reference yield:

: C₄₀H₆₆O₁₃

: 97850-05-0
bryostatin 7

Guidance literature:: Multi-step reaction with 16 steps

1: imidazole / dimethylformamide

2: pyridine, DMAP

3: n-Bu₄NF / tetrahydrofuran

4: MnO₂ / tetrahydrofuran

5: NaCN, AcOH

6: (COCl)2, Et₃N / dimethylsulfoxide; CH₂Cl₂ / -78 - 0 °C

7: i-Pr₂EtN / diethyl ether / -100 - -78 °C

8: 40 percent / camphorsulfonic acid (CSA), MeOH

9: lutidine / CH₂Cl₂ / 0 °C

10: Hg(O₂CCF₃)2, Na₂HPO₄ / tetrahydrofuran

11: HF*pyridine / tetrahydrofuran / -20 °C

12: 51 percent / dicyclohexylcarbodiimide (DCC), pyridinium p-toluenesulfonate (PPTS), pyridine / 1,2-dichloro-ethane / Heating

13: 54 percent / K₂CO₃ / methanol

14: Et₃N, DMAP / dimethylformamide

15: pyridine

16: HF / acetonitrile

With pyridine; 1H-imidazole; methanol; dmap; manganese(IV) oxide; disodium hydrogenphosphate; oxalyl dichloride; lutidine; camphor-10-sulfonic acid; hydrogen fluoride; sodium cyanide; tetrabutyl ammonium fluoride; mercury(II) trifluoroacetate; pyridinium p-toluenesulfonate; potassium carbonate; pyridine hydrogenfluoride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00176a058

Reference yield:

: 130219-50-0
C₄₂H₆₈O₁₄

: 97850-05-0
bryostatin 7

Guidance literature:: Multi-step reaction with 13 steps

1: MnO₂ / tetrahydrofuran

2: NaCN, AcOH

3: (COCl)2, Et₃N / dimethylsulfoxide; CH₂Cl₂ / -78 - 0 °C

4: i-Pr₂EtN / diethyl ether / -100 - -78 °C

5: 40 percent / camphorsulfonic acid (CSA), MeOH

6: lutidine / CH₂Cl₂ / 0 °C

7: Hg(O₂CCF₃)2, Na₂HPO₄ / tetrahydrofuran

8: HF*pyridine / tetrahydrofuran / -20 °C

9: 51 percent / dicyclohexylcarbodiimide (DCC), pyridinium p-toluenesulfonate (PPTS), pyridine / 1,2-dichloro-ethane / Heating

10: 54 percent / K₂CO₃ / methanol

11: Et₃N, DMAP / dimethylformamide

12: pyridine

13: HF / acetonitrile

With pyridine; methanol; dmap; manganese(IV) oxide; disodium hydrogenphosphate; oxalyl dichloride; lutidine; camphor-10-sulfonic acid; hydrogen fluoride; sodium cyanide; mercury(II) trifluoroacetate; pyridinium p-toluenesulfonate; potassium carbonate; pyridine hydrogenfluoride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00176a058