3-Flavanone

Base Information

• Chemical Name: 3-Flavanone
• CAS No.: 20760-17-2
• Molecular Formula: C₁₅H₁₂O₂
• Molecular Weight: 224.259
• DSSTox Substance ID: DTXSID00487998
• Mol file: 20760-17-2.mol

Synonyms:3-Flavanone;flavan-3-one;20760-17-2;2-phenyl-3-chromanone;SCHEMBL19746;DTXSID00487998;CVYNTXBILWATKN-UHFFFAOYSA-N

Chemical Property of 3-Flavanone

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 224.083729621
• Heavy Atom Count: 17
• Complexity: 281

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=CC=CC=C2OC(C1=O)C3=CC=CC=C3

Technology Process of 3-Flavanone

There total 5 articles about 3-Flavanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-diazo-3-phenoxy-3-phenyl-2-propanone (87385-62-4) → 2-phenyl-3-oxo-3,4-dihydro-2H-1-benzopyran (20760-17-2) + 2-phenyl-2,8H-cycloheptafuran-3-one (107449-23-0)

Guidance literature:

copper(II) hexafluoro-2,4-pentanedionate; In dichloromethane; at 15 - 25 ℃; for 0.0666667h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)87658-4

Reference yield:

(2S,3R)-2-Phenyl-chroman-3-ol → 2-phenyl-3-oxo-3,4-dihydro-2H-1-benzopyran (20760-17-2)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmcl.2014.03.088

Reference yield:

2-phenylchromene (93514-42-2,6053-99-2) → 2-phenyl-3-oxo-3,4-dihydro-2H-1-benzopyran (20760-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: borane-THF / tetrahydrofuran / 0 °C

1.2: 0 °C

2.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

With borane-THF; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2014.03.088

upstream raw materials:

2-phenyl-3-nitro-2H-chromene

1-diazo-3-phenoxy-3-phenyl-2-propanone

2-phenylchromene

Downstream raw materials:

cis-flavan-3-ol