Unii-6wjy4C4bcq

Base Information

Chemical Name:Unii-6wjy4C4bcq
CAS No.:53898-64-9
Molecular Formula:C15H18FNO2
Molecular Weight:263.312
Hs Code.:
UNII:6WJY4C4BCQ

Synonyms:UNII-6WJY4C4BCQ;6WJY4C4BCQ;RTI-104;RTI-4229-104;53898-64-9;3-(4-Fluorophenyl)-8-methyl-8-azabicyclo(3.2.1)octane-2-carboxylate;(1R,2S,3S,5S)-3-(4-Fluorophenyl)-8-methyl-8-azabicyclo(3.2.1)octane-2-carboxylic acid;8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(4-fluorophenyl)-8-methyl-, (1R,2S,3S,5S)-;(1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid;SCHEMBL3424994;UAVJURKSCUOSRS-DGAVXFQQSA-N;2beta-Carboxy-3beta-(4-fluorophenyl) Tropane;3b-(4-fluoro-phenyl)tropane-2b-carboxylic acid

Suppliers and Price of Unii-6wjy4C4bcq

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of Unii-6wjy4C4bcq

Chemical Property:

XLogP3:0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:263.13215698
Heavy Atom Count:19
Complexity:354

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C2CCC1C(C(C2)C3=CC=C(C=C3)F)C(=O)O
Isomeric SMILES:CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)C3=CC=C(C=C3)F)C(=O)O

Technology Process of Unii-6wjy4C4bcq

There total 8 articles about Unii-6wjy4C4bcq which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 50370-59-7
2β-carbomethoxy-3β-(4-fluorophenyl)tropane

: 53898-64-9
2β-carboxy-3β-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane

Guidance literature:: With water; In 1,4-dioxane; for 24h; Heating;
DOI:10.1021/jm0301484

Reference yield:

: 85506-18-9
(1R)-(-)-2-carbomethoxy-3-tropinone

: 53898-64-9
2β-carboxy-3β-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium bistrimethylsilylamide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 97 percent / tetrahydrofuran / -78 - 22 °C

2.1: 89 percent / LiCl; aq. Na₂CO₃; Pd₂dba3 / various solvent(s) / 3 h / Heating

3.1: SmI₂ / tetrahydrofuran / 0.75 h / -78 °C

3.2: 34 percent / MeOH / tetrahydrofuran / 2 h

4.1: 95 percent / H₂O / dioxane / 24 h / Heating

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; samarium diiodide; water; sodium hexamethyldisilazane; sodium carbonate; lithium chloride; In tetrahydrofuran; 1,4-dioxane; 2.1: Suzuki coupling;
DOI:10.1021/jm0301484

Reference yield:

: 168143-68-8
O-1104

: 53898-64-9
2β-carboxy-3β-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 2 steps

1.1: SmI₂ / tetrahydrofuran / 0.75 h / -78 °C

1.2: 34 percent / MeOH / tetrahydrofuran / 2 h

2.1: 95 percent / H₂O / dioxane / 24 h / Heating

With samarium diiodide; water; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm0301484