4,4-Dimethyl-1,2,3,4-tetrahydronaphthalen-1-ol

Base Information

Chemical Name:4,4-Dimethyl-1,2,3,4-tetrahydronaphthalen-1-ol
CAS No.:53952-18-4
Molecular Formula:C12H16O
Molecular Weight:176.258
Hs Code.:
DSSTox Substance ID:DTXSID50505419
Nikkaji Number:J741.857D

Synonyms:53952-18-4;SCHEMBL6652087;DTXSID50505419;MEFVOBKOEJGUQI-UHFFFAOYSA-N;1,2,3,4-tetrahydro-4,4-dimethyl-1-naphthol;4,4-Dimethyl-1,2,3,4-tetrahydronaphthalen-1-ol

Suppliers and Price of 4,4-Dimethyl-1,2,3,4-tetrahydronaphthalen-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,4-Dimethyl-1,2,3,4-tetrahydronaphthalen-1-ol

Chemical Property:

Boiling Point:102-104 °C(Press: 15 Torr)
PSA：20.23000
Density:1.026±0.06 g/cm3(Predicted)
LogP:2.79140
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:176.120115130
Heavy Atom Count:13
Complexity:186

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CCC(C2=CC=CC=C21)O)C

Technology Process of 4,4-Dimethyl-1,2,3,4-tetrahydronaphthalen-1-ol

There total 1 articles about 4,4-Dimethyl-1,2,3,4-tetrahydronaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3123-97-5
dihydro-5,5-dimethyl-2(3H)-furanone

: 53952-18-4
4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride / Inert atmosphere; Reflux

2: sodium tetrahydroborate / tetrahydrofuran / Inert atmosphere

With aluminum (III) chloride; sodium tetrahydroborate; In tetrahydrofuran;
DOI:10.1021/om400485a

Reference yield:

: 53952-18-4
4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-ol

: 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(2-methylpyrimidin-5-yl)-2-phenylpyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 1.5 h / 90 °C

2: oxone; sodium hydrogencarbonate / acetone; water / 17 h / 1 - 30 °C / Cooling with ice

3: ammonium hydroxide / ethanol / 1 h / 90 °C / Sealed tube

4: acetone; water / 90 °C

5: triethylamine / 1-methyl-pyrrolidin-2-one / 18.5 h / 40 °C

With ammonium hydroxide; oxone; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; In 1-methyl-pyrrolidin-2-one; ethanol; water; acetone; toluene;

Reference yield:

: 53952-18-4
4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-ol

: 1-((1R,2R)-2-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)-3-(5-methyl-6-(1-methyl-1H-pyrazol-4-yl)-2-phenylpyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 1.5 h / 90 °C

2: oxone; sodium hydrogencarbonate / acetone; water / 17 h / 1 - 30 °C / Cooling with ice

3: ammonium hydroxide / ethanol / 1 h / 90 °C / Sealed tube

4: acetone; water / 90 °C

5: triethylamine / 1-methyl-pyrrolidin-2-one / 1 h / 40 °C

With ammonium hydroxide; oxone; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; In 1-methyl-pyrrolidin-2-one; ethanol; water; acetone; toluene;