1-[(4-Methoxyphenyl)-phenylmethyl]piperazine

Base Information

• Chemical Name: 1-[(4-Methoxyphenyl)-phenylmethyl]piperazine
• CAS No.: 54041-93-9
• Molecular Formula: C₁₈H₂₂N₂O
• Molecular Weight: 282.385
• DSSTox Substance ID: DTXSID20389905

Synonyms:54041-93-9;1-[(4-methoxyphenyl)-phenylmethyl]piperazine;1-((4-Methoxyphenyl)(phenyl)methyl)piperazine;1-[(4-Methoxy-phenyl)-phenyl-methyl]-piperazine;1-[(4-methoxyphenyl)(phenyl)methyl]piperazine;4-METHOXY-1-(PHENYLPIPERAZINYLMETHYL)BENZENE;SCHEMBL1741596;DTXSID20389905;QEBOYBVMAZLNLX-UHFFFAOYSA-N;HMS1704N07;AR3980;AKOS003587305

Chemical Property of 1-[(4-Methoxyphenyl)-phenylmethyl]piperazine

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 282.173213330
• Heavy Atom Count: 21
• Complexity: 290

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)N3CCNCC3

Technology Process of 1-[(4-Methoxyphenyl)-phenylmethyl]piperazine

There total 2 articles about 1-[(4-Methoxyphenyl)-phenylmethyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) + 4-methoxybenzhydryl chloride (6731-11-9) → 1-(p-Methoxybenzhydryl)piperazine (54041-93-9)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; Reflux;

DOI:10.1016/j.bmcl.2010.01.008

Reference yield:

4-ethoxycarbonylpiperazine (120-43-4) + 4-methoxybenzhydryl chloride (6731-11-9) → 1-(p-Methoxybenzhydryl)piperazine (54041-93-9)

Guidance literature:

With potassium hydroxide; triethylamine; toluene;

Reference yield: 28.0%

1-(p-Methoxybenzhydryl)piperazine (54041-93-9) + 4-<(2-chloroethyl)amino>-2,6-dimethyl-3-nitropyridine (110629-58-8) → (2,6-Dimethyl-3-nitro-pyridin-4-yl)-(2-{4-[(4-methoxy-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethyl)-amine; hydrochloride (125742-55-4)

Guidance literature:

With hydrogenchloride; triethylamine; In N,N-dimethyl-formamide; for 2h; Heating;

DOI:10.1016/0223-5234(89)90003-2

upstream raw materials:

4-ethoxycarbonylpiperazine

4-methoxybenzhydryl chloride

piperazine

Downstream raw materials:

4-{4-[(4-Methoxy-phenyl)-phenyl-methyl]-piperazin-1-yl}-butylamine

(2,6-Dimethyl-3-nitro-pyridin-4-yl)-(2-{4-[(4-methoxy-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethyl)-amine; hydrochloride

(E)-N-(4-{4-[(4-Methoxy-phenyl)-phenyl-methyl]-piperazin-1-yl}-butyl)-3-pyridin-3-yl-acrylamide

C₃₃H₃₄N₂O₂

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