4-(2,4,6-TRIMETHYL-PHENYL)-THIAZOL-2-YLAMINE

Base Information

• Chemical Name: 4-(2,4,6-TRIMETHYL-PHENYL)-THIAZOL-2-YLAMINE
• CAS No.: 81529-60-4
• Molecular Formula: C12H14N2S
• Molecular Weight: 218.323
• Hs Code.: 2934100090
• Mol file: 81529-60-4.mol

Synonyms:4-(2,4,6-trimethylphenyl)thiazol-2-ylamine;4-mesityl-thiazol-2-ylamine;2-amino-4-(2,4,6-trimethylphenyl)thiazole;F0017-0517;4-(2,4,6-trimethylphenyl)-2-aminothiazole;4-Mesityl-thiazol-2-ylamin;4-Mesityl-2-thiazolamine;4-mesitylthiazol-2-amine;4-Mesityl-1,3-thiazol-2-amine;

Chemical Property of 4-(2,4,6-TRIMETHYL-PHENYL)-THIAZOL-2-YLAMINE

Chemical Property:

• Vapor Pressure: 4.11E-05mmHg at 25°C
• Boiling Point: 351.4°Cat760mmHg
• Flash Point: 166.3°C
• PSA: 67.88000
• Density: 1.158g/cm³
• LogP: 3.24760

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-(2,4,6-Trimethyl-phenyl)-thiazol-2-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2,4,6-TRIMETHYL-PHENYL)-THIAZOL-2-YLAMINE

There total 4 articles about 4-(2,4,6-TRIMETHYL-PHENYL)-THIAZOL-2-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-1-(2,4,6-trimethylphenyl)ethanone (4225-92-7) + thiourea (17356-08-0) → 4-(2,4,6-trimethylphenyl)thiazol-2-ylamine (81529-60-4)

Guidance literature:

In ethanol; Reflux; Inert atmosphere;

DOI:10.1021/jm8015969

Reference yield:

2,4,6-Trimethylacetophenone (1667-01-2,51885-97-3) → 4-(2,4,6-trimethylphenyl)thiazol-2-ylamine (81529-60-4)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(ll) bromide / ethyl acetate / 1.5 h / Reflux

2: ethanol / 2 h / Reflux

With copper(ll) bromide; In ethanol; ethyl acetate;

Reference yield:

1,3,5-trimethyl-benzene (108-67-8) → 4-(2,4,6-trimethylphenyl)thiazol-2-ylamine (81529-60-4)

Guidance literature:

Multi-step reaction with 3 steps

1: bismuth(III) chloride / 70 °C

2: copper(ll) bromide / ethyl acetate / 1.5 h / Reflux

3: ethanol / 2 h

With bismuth(III) chloride; copper(ll) bromide; In ethanol; ethyl acetate;

DOI:10.1021/jm401990s

upstream raw materials:

2-chloro-1-(2,4,6-trimethyl-phenyl)-ethanone

thiourea

2-bromo-1-(2,4,6-trimethylphenyl)ethanone

2,4,6-Trimethylacetophenone

Downstream raw materials:

pyridine-2-carboxylic acid [4-(2,4,6-trimethylphenyl)thiazol-2-yl]amide

N-[4-(2,4,6-trimethylphenyl)thiazol-2-yl]nicotinamide

N-[4-(2,4,6-trimethylphenyl)-2-thiazolyl]-benzamide

2-methoxy-N-[4-(2,4,6-trimethylphenyl)thiazol-2-yl]benzamide