2-Amino-5-bromobenzenesulfonamide

Base Information

• Chemical Name: 2-Amino-5-bromobenzenesulfonamide
• CAS No.: 54734-84-8
• Molecular Formula: C6H7BrN2O2S
• Molecular Weight: 251.104
• Hs Code.: 2935909099
• European Community (EC) Number: 637-228-0
• DSSTox Substance ID: DTXSID00356231
• Wikidata: Q82135475
• Mol file: 54734-84-8.mol

Synonyms:2-amino-5-bromobenzenesulfonamide;54734-84-8;2-Amino-5-bromobenzenesulphonamide;2-amino-5-bromobenzene-1-sulfonamide;SCHEMBL1522775;DTXSID00356231;Benzene, 1-bromo-2-cyclopropyl-;BGILQOXCWMHWOM-UHFFFAOYSA-N;MFCD03426835;AKOS010212633;AT23123;PS-4109;2-Amino-5-bromobenzenesulfonamide, 97%;EN300-272696;J-507911

Chemical Property of 2-Amino-5-bromobenzenesulfonamide

Chemical Property:

• Vapor Pressure: 2.07E-07mmHg at 25°C
• Melting Point: 170-176°C
• Boiling Point: 424.4oC at 760 mmHg
• Flash Point: 210.5oC
• PSA: 94.56000
• Density: 1.834g/cm3
• LogP: 3.04100
• Storage Temp.: 2-8°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 249.94116
• Heavy Atom Count: 12
• Complexity: 249

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-bromobenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Br)S(=O)(=O)N)N

Technology Process of 2-Amino-5-bromobenzenesulfonamide

There total 16 articles about 2-Amino-5-bromobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-AMINOBENZENESULFONAMIDE (3306-62-5) → 2-amino-5-bromobenzenesulfonamide (54734-84-8)

Guidance literature:

With bromine; acetic acid; for 0.5h;

Reference yield: 42.0%

7-bromo-3-oxo-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (14141-71-0) → 2-amino-5-bromobenzenesulfonamide (54734-84-8)

Guidance literature:

With sulfuric acid; for 4h; Heating;

DOI:10.1016/j.bmcl.2006.04.022

Reference yield:

4-bromo-2-fluoronitrobenzene (321-23-3) → 2-amino-5-bromobenzenesulfonamide (54734-84-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium sulfite / water; ethanol / 15 h / 70 °C / Inert atmosphere; Sealed tube

2: thionyl chloride; N,N-dimethyl-formamide / toluene / 4 h / Inert atmosphere; Sealed tube; Reflux

3: ammonium hydroxide / tetrahydrofuran; toluene; water / 2 h / -10 °C / Inert atmosphere; Sealed tube

4: hydrogen iodide / water / 4 h / 90 °C / Inert atmosphere; Sealed tube

With ammonium hydroxide; thionyl chloride; hydrogen iodide; N,N-dimethyl-formamide; sodium sulfite; In tetrahydrofuran; ethanol; water; toluene;

upstream raw materials:

2-AMINOBENZENESULFONAMIDE

7-bromo-3-oxo-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

4-bromo-aniline

2-Nitrobenzenesulfonamide

Downstream raw materials:

N-[2-(aminosulfonyl)phenyl]-1-(benzyloxy)-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

N-[2-(aminosulfonyl)phenyl]-4-hydroxy-1-isobutoxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

N-[2-(aminosulfonyl)phenyl]-4-hydroxy-2-oxo-1-propoxy-1,2-dihydroquinoline-3-carboxamide

5-bromo-2-(3-methylbutyrylamino)benzenesulfonamide