magnolamine

Base Information

• Chemical Name: magnolamine
• CAS No.: 573-73-9
• Molecular Formula: C37H42N2O7
• Molecular Weight: 626.74
• Mol file: 573-73-9.mol

Synonyms:5-((S)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydro-[1]isoquinolylmethyl)-4-(4-((S)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydro-[1]isoquinolylmethyl]-phenoxy)-2-methoxy-phenol;Magnolamin;5-((S)-7-Hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydro-[1]isochinolylmethyl)-4-(4-((S)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4-tetrahydro-[1]isochinolylmethyl]-phenoxy)-2-methoxy-phenol;

Chemical Property of magnolamine

Chemical Property:

• Melting Point: 117-9°C
• PSA: 104.09000
• LogP: 6.04070

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: This bisbenzylisoquinoline alkaloid is found in the benzene-soluble portion of the total alkaloids extracted from Magnolia fuscata. When recrystallized from C6H6 it yields fine, colourless needles, soluble in alkalies, CHC13 and EtOH. It is dextrorotatory with [α]D + 111.6° and yields a crystalline picrate, m.p. 142- SoC (dec.); a picrolonate, m.p. 163-4°C and a tetramethyl ether, m.p. lSI-2°C. The latter may be oxidized by KMn04 in Me2CO to give 1-keto-6:7-dimethoxy- 2-methyltetrahydroisoquinoline, m.p. 124-5°C and magnolaminic acid, C16H1407, m.p. 280-loC. The alkaloid acts as a cardiac depressant at between 10 to 500 parts per million.

Technology Process of magnolamine

There total 4 articles about magnolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.3%

tribenzylmagnolamine (80248-83-5) → magnolamine (573-73-9)

Guidance literature:

With hydrogenchloride; In ethanol;

Reference yield:

(S)-1-(4-hydroxybenzyl)-2-methyl-6-methoxy-7-benzyloxy-1,2,3,4-tetrahydro-isoquinoline (17958-52-0) → magnolamine (573-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 3.6 percent / cupric oxide, pyridine, K₂CO₃ / 24 h / Heating

2: 58.3 percent / HCl / ethanol

With pyridine; hydrogenchloride; potassium carbonate; copper(II) oxide; In ethanol;

Reference yield:

(S)-7-Benzyloxy-1-(5-benzyloxy-2-bromo-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline (19777-92-5) → magnolamine (573-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) HCHO, 2.) NaBH₄

2: 3.6 percent / cupric oxide, pyridine, K₂CO₃ / 24 h / Heating

3: 58.3 percent / HCl / ethanol

With pyridine; hydrogenchloride; sodium tetrahydroborate; formaldehyd; potassium carbonate; copper(II) oxide; In ethanol;

upstream raw materials:

tribenzylmagnolamine

(S)-1-(4-hydroxybenzyl)-2-methyl-6-methoxy-7-benzyloxy-1,2,3,4-tetrahydro-isoquinoline

(S)-7-Benzyloxy-1-(5-benzyloxy-2-bromo-4-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline

L-(+)-6'-bromo-O,O-dibenzylreticuline

Refernces