Clopipazan

Base Information

• Chemical Name: Clopipazan
• CAS No.: 60085-78-1
• Molecular Formula: C19H18ClNO
• Molecular Weight: 311.81
• Hs Code.: 2934999090
• Mol file: 60085-78-1.mol

Synonyms:Clopipazan

Chemical Property of Clopipazan

Chemical Property:

• Vapor Pressure: 4.33E-08mmHg at 25°C
• Boiling Point: 444.3°C at 760 mmHg
• Flash Point: 222.5°C
• PSA: 12.47000
• Density: 1.249g/cm³
• LogP: 4.91110

Purity/Quality:

99% ^*data from raw suppliers

CLOPIPAZAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antipsychotic.

Technology Process of Clopipazan

There total 7 articles about Clopipazan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-chloro-9-(1-methyl-piperidin-4-yl)-xanthen-9-ol (60086-24-0) → Clopipazan (60085-78-1)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; acetonitrile; Heating;

DOI:10.1016/0040-4039(96)01068-4

Reference yield: 90.0%

1-Methyl-4-piperidone (1445-73-4) + 2-chloro-10-(dimethoxyphosphinyl)-9,10-dihydro-9-oxaanthracene (81642-93-5) → Clopipazan (60085-78-1)

Guidance literature:

With sodium methylate; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1021/jo00135a030

Reference yield:

2-chloroxanthen-9-one (13210-15-6) → Clopipazan (60085-78-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 94.4 percent / NaOH, zinc dust, methanol / 4 h / Ambient temperature

2: HClO₄ / diethyl ether / -78 °C

3: 70.6 percent / acetonitrile / Ambient temperature

4: 90 percent / NaOMe / tetrahydrofuran / 4 h / Ambient temperature; other phosphonate, var. aldehydes and ketones; other reagent

With methanol; sodium hydroxide; perchloric acid; sodium methylate; zinc; In tetrahydrofuran; diethyl ether; acetonitrile;

DOI:10.1021/jo00135a030

upstream raw materials:

1-Methyl-4-piperidone

2-chloro-10-(dimethoxyphosphinyl)-9,10-dihydro-9-oxaanthracene

2-chloro-9-(1-methyl-piperidin-4-yl)-xanthen-9-ol

ethyl 1-methylisonipecotate