Quinazolinium, 3,4-dihydro-3-(4-chlorophenyl)-1-((2,4-dimethoxyphenyl)methyl)-2-methyl-4-oxo-, perchlorate

Base Information

• Chemical Name: Quinazolinium, 3,4-dihydro-3-(4-chlorophenyl)-1-((2,4-dimethoxyphenyl)methyl)-2-methyl-4-oxo-, perchlorate
• CAS No.: 139755-24-1
• Molecular Formula: C24H22Cl2N2O7
• Molecular Weight: 521.3467
• DSSTox Substance ID: DTXSID30161158
• Mol file: 139755-24-1.mol

Synonyms:Quinazolinium, 3,4-dihydro-3-(4-chlorophenyl)-1-((2,4-dimethoxyphenyl)methyl)-2-methyl-4-oxo-, perchlorate;1-(2',4'-Dimethoxybenzyl)-2-methyl-3-(4'-chlorophenyl)-4(3H)-quinazolinium perchlorate;139755-24-1;C24H22ClN2O3.ClO4;DTXSID30161158;LS-140258;Quinazolinium, 3,4-dihydro-3-(4-chlorophenyl)-1-((2,4-dimethoxyphenyl)methyl)-2-methyl-4-oxo-,perchlorate

Chemical Property of Quinazolinium, 3,4-dihydro-3-(4-chlorophenyl)-1-((2,4-dimethoxyphenyl)methyl)-2-methyl-4-oxo-, perchlorate

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 520.0804064
• Heavy Atom Count: 35
• Complexity: 742

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=[N+](C2=CC=CC=C2C(=O)N1C3=CC=C(C=C3)Cl)CC4=C(C=C(C=C4)OC)OC.[O-]Cl(=O)(=O)=O

Technology Process of Quinazolinium, 3,4-dihydro-3-(4-chlorophenyl)-1-((2,4-dimethoxyphenyl)methyl)-2-methyl-4-oxo-, perchlorate

There total 5 articles about Quinazolinium, 3,4-dihydro-3-(4-chlorophenyl)-1-((2,4-dimethoxyphenyl)methyl)-2-methyl-4-oxo-, perchlorate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

N-acetyl-N-(2',4'-dimethoxybenzyl)anthranil-4-chloroanilide (143424-27-5) → 1-(2',4'-dimethoxybenzyl)-2-methyl-3-(4'-chlorophenyl)-4(3H)-quinazolinonium perchlorate (139755-24-1)

Guidance literature:

With perchloric acid; In methanol; at 70 - 80 ℃; for 0.5h;

DOI:10.1007/BF00772940

Reference yield:

2-amino-N-(4-chlorophenyl)benzamide (4943-86-6) → 1-(2',4'-dimethoxybenzyl)-2-methyl-3-(4'-chlorophenyl)-4(3H)-quinazolinonium perchlorate (139755-24-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / ethanol / 0.5 h / Ambient temperature

2: 68 percent / sodium borohydride / ethanol / 2 h / Ambient temperature

3: 57 percent / 0.75 h / Heating

4: 98.3 percent / 57percent aq. perchloric acid / methanol / 0.5 h / 70 - 80 °C

With sodium tetrahydroborate; perchloric acid; In methanol; ethanol;

DOI:10.1007/BF00772940

Reference yield:

N-2,4-dimethoxybenzylideneanthranil-4-chloroanilide (143424-17-3) → 1-(2',4'-dimethoxybenzyl)-2-methyl-3-(4'-chlorophenyl)-4(3H)-quinazolinonium perchlorate (139755-24-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / sodium borohydride / ethanol / 2 h / Ambient temperature

2: 57 percent / 0.75 h / Heating

3: 98.3 percent / 57percent aq. perchloric acid / methanol / 0.5 h / 70 - 80 °C

With sodium tetrahydroborate; perchloric acid; In methanol; ethanol;

DOI:10.1007/BF00772940

upstream raw materials:

N-acetyl-N-(2',4'-dimethoxybenzyl)anthranil-4-chloroanilide

2-amino-N-(4-chlorophenyl)benzamide

N-2,4-dimethoxybenzylideneanthranil-4-chloroanilide

N-2,4-dimethoxybenzylanthranil-4-chloroanilide

Refernces