Cambinol

Base Information

• Chemical Name: Cambinol
• CAS No.: 14513-15-6
• Molecular Formula: C₂₁H₁₆N₂O₂S
• Molecular Weight: 360.436
• European Community (EC) Number: 634-301-9
• NSC Number: 112546
• UNII: 8S2PHY4FNC
• DSSTox Substance ID: DTXSID40390573
• Nikkaji Number: J3.133.011D
• Pharos Ligand ID: D3HN11YL81HA
• Metabolomics Workbench ID: 155521
• ChEMBL ID: CHEMBL491960
• Mol file: 14513-15-6.mol

Synonyms:cambinol

Chemical Property of Cambinol

Chemical Property:

• Vapor Pressure: 2.12E-18mmHg at 25°C
• Melting Point: 235 °C(dec.)
• Boiling Point: 667°Cat760mmHg
• Flash Point: 357.2°C
• PSA: 100.97000
• Density: 1.41g/cm³
• LogP: 4.54910
• Storage Temp.: Room temp
• Solubility.: DMSO: ≥10mg/mL
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 360.09324893
• Heavy Atom Count: 26
• Complexity: 597

Purity/Quality:

98%,99%, ^*data from raw suppliers

SIRT1/2 Inhibitor IV, Cambinol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O
• Uses: SIRT1/2 Inhibitor IV, Cambinol is an inhibitor of SIRT1, SIRT2, and SIRT5. Cambinol has been used:as an inhibitor of sirutins (SIRT1 and 2) in hepatocarcinoma cell lines to test its effect on cellular viability and colony formationas a SIRT1 and SIRT2 inhibitor to test its effect on frizzled 7 (FZD7) expression in the breast cancer cells MDA-MB-231 and T-47D cellsas a sirutin inhibitor in L929 cells to test its protective effect against tumor necrosis factor (TNF)-induced cell death

Technology Process of Cambinol

There total 1 articles about Cambinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-Mercapto-4-phenyl-5-(2-hydroxy-naphthyl-1-methyl)-6-hydroxy-pyrimidin (14513-15-6)

Guidance literature:

3-Benzoyl-3,4-dihydro-5,6-benzocumarin, Thioharnstoff, Na-ethylat; Ausb.: 67percent;