2-Butenal, 4-phenyl-, (E)-

Base Information

• Chemical Name: 2-Butenal, 4-phenyl-, (E)-
• CAS No.: 55177-35-0
• Molecular Formula: C10H10O
• Molecular Weight: 146.189
• Mol file: 55177-35-0.mol

Synonyms:

Chemical Property of 2-Butenal, 4-phenyl-, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Butenal, 4-phenyl-, (E)-

There total 51 articles about 2-Butenal, 4-phenyl-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-phenylbut-3-yn-2-yl acetate (289894-92-4) → (E)-4-phenyl-2-butenal (55177-35-0)

Guidance literature:

With water; silver hexafluoroantimonate; In tetrahydrofuran; at 60 ℃; for 8h;

DOI:10.1002/chem.200700134

Reference yield: 91.0%

tris(ethoxyvinyl)borane (1151545-40-2) + phenylacetaldehyde (122-78-1) → (E)-4-phenyl-2-butenal (55177-35-0)

Guidance literature:

tris(ethoxyvinyl)borane; With diethylzinc; In toluene; at -78 ℃; for 0.333333h; Inert atmosphere;

phenylacetaldehyde; In toluene; at -78 - 20 ℃; for 14h; Inert atmosphere;

With hydrogenchloride; water; In diethyl ether; toluene; at 0 ℃; pH=> 4; Inert atmosphere;

DOI:10.1021/ol9005757

Reference yield: 89.0%

allylbenzene (300-57-2,57807-91-7) + trans-Crotonaldehyde (123-73-9,4170-30-3) → (E)-4-phenyl-2-butenal (55177-35-0)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 12h; Reflux;

DOI:10.3390/molecules23061440

upstream raw materials:

(Z)-1,4-dihydroxy-1-phenylbut-2-ene

(1E,3E)-4-phenylbuta-1,3-dien-1-yl acetate

trans-(4-Phenyl-buten-⁽²⁾-yl)dithiocarbamat

C₁₇H₁₈OS

Downstream raw materials:

4-phenyl-crotonaldehyde-semicarbazone

naphthalene

(2R,4R)-4-benzyl-5-oxo-2,3,4,5,6,7-hexahydrocyclopenta[b]pyran-2-yl acetate

(S)-2-benzyl-3-formyl-4-methylcyclopent-3-ene-1,1-dicarbonitrile

Refernces

• 1、 Komori, Saki,Yamaguchi, Yoshiko,Murakami, Yuka,Kataoka, Yasutaka,Ura, Yasuyuki. "Palladium/Copper-catalyzed Oxidation of Aliphatic Terminal Alkenes to Aldehydes Assisted by p-Benzoquinone". . p. 3946 - 3955. Retrieved 2020/07/06.
• 2、 Gao, Haoling,Yu, Jiangang,Ge, Chengsheng,Jiang, Qun. "Practical asymmetric synthesis of Sitagliptin phosphate monohydrate". . . Retrieved 2018/06/29.