Methanone, (4-chlorophenyl)-4-quinazolinyl-

Base Information

• Chemical Name: Methanone, (4-chlorophenyl)-4-quinazolinyl-
• CAS No.: 55276-59-0
• Molecular Formula: C15H9ClN2O
• Molecular Weight: 268.702
• DSSTox Substance ID: DTXSID40480165
• Nikkaji Number: J463.553A

Synonyms:55276-59-0;Methanone, (4-chlorophenyl)-4-quinazolinyl-;DTXSID40480165

Chemical Property of Methanone, (4-chlorophenyl)-4-quinazolinyl-

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 268.0403406
• Heavy Atom Count: 19
• Complexity: 328

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=NC=N2)C(=O)C3=CC=C(C=C3)Cl

Technology Process of Methanone, (4-chlorophenyl)-4-quinazolinyl-

There total 9 articles about Methanone, (4-chlorophenyl)-4-quinazolinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Benzoic acid (4-chloro-phenyl)-quinazolin-4-yl-methyl ester (98512-26-6) → (4-chloro-phenyl)-quinazolin-4-yl-methanone (55276-59-0)

Guidance literature:

With sodium hydroxide; In methanol; for 0.5h; Heating;

Reference yield: 85.0%

4-chloroquinazoline (5190-68-1) + 4-chlorobenzaldehyde (104-88-1) → (4-chloro-phenyl)-quinazolin-4-yl-methanone (55276-59-0)

Guidance literature:

With 1,3-dimethylbenzimidazolium Iodide; sodium hydride; In tetrahydrofuran; for 1h; Heating;

DOI:10.1248/cpb.40.43

Reference yield: 77.0%

4-chloroquinazoline (5190-68-1) + 1,3-dimethyl-2-(α-hydroxy-4-chlorobenzyl)benzimidazolium iodide → (4-chloro-phenyl)-quinazolin-4-yl-methanone (55276-59-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 1h; Heating;

DOI:10.3987/COM-96-S40

upstream raw materials:

4-chloroquinazoline

4-chlorobenzaldehyde

Benzoic acid (4-chloro-phenyl)-quinazolin-4-yl-methyl ester

1-Methylbenzimidazole

Downstream raw materials:

1-(4-Chloro-phenyl)-2-phenyl-1-quinazolin-4-yl-ethanol

4-(para-chloro)phenylquinazoline

quinazoline

4-(4-Chloro-phenyl)-3,4-dihydro-quinazoline-4-carboxylic acid

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