Methanone, (2-chlorophenyl)-4-quinazolinyl-

Base Information

• Chemical Name: Methanone, (2-chlorophenyl)-4-quinazolinyl-
• CAS No.: 55276-60-3
• Molecular Formula: C15H9ClN2O
• Molecular Weight: 268.702
• DSSTox Substance ID: DTXSID80480164
• Nikkaji Number: J463.552C
• Mol file: 55276-60-3.mol

Synonyms:55276-60-3;Methanone, (2-chlorophenyl)-4-quinazolinyl-;DTXSID80480164

Chemical Property of Methanone, (2-chlorophenyl)-4-quinazolinyl-

Chemical Property:

• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 268.0403406
• Heavy Atom Count: 19
• Complexity: 336

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=NC=N2)C(=O)C3=CC=CC=C3Cl

Technology Process of Methanone, (2-chlorophenyl)-4-quinazolinyl-

There total 4 articles about Methanone, (2-chlorophenyl)-4-quinazolinyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-chloroquinazoline (5190-68-1) + 2-chloro-benzaldehyde (89-98-5) → (2-chloro-phenyl)-quinazolin-4-yl-methanone (55276-60-3)

Guidance literature:

With 1,3-dimethylbenzimidazolium Iodide; sodium hydride; In N,N-dimethyl-formamide; for 0.166667h; Ambient temperature;

DOI:10.1248/cpb.40.43

Reference yield: 73.0%

Benzoic acid (2-chloro-phenyl)-quinazolin-4-yl-methyl ester (98512-25-5) → (2-chloro-phenyl)-quinazolin-4-yl-methanone (55276-60-3)

Guidance literature:

With sodium hydroxide; In methanol; for 0.5h; Heating;

Reference yield:

3-benzoyl-3,4-dihydro-4-quinazolinecarbonitrile (92736-32-8) → (2-chloro-phenyl)-quinazolin-4-yl-methanone (55276-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide

2: 73 percent / NaOH / methanol / 0.5 h / Heating

With sodium hydroxide; sodium hydride; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

4-chloroquinazoline

2-chloro-benzaldehyde

Benzoic acid (2-chloro-phenyl)-quinazolin-4-yl-methyl ester

3-benzoyl-3,4-dihydro-4-quinazolinecarbonitrile

Downstream raw materials:

4-(2-Chloro-phenyl)-3,4-dihydro-quinazoline-4-carboxylic acid

4-(2-chlorophenyl)quinazoline