[1,2,4]Triazolo[1,5-a]pyrimidine-2-carboxaldehyde, 5,7-dimethyl-

Base Information

• Chemical Name: [1,2,4]Triazolo[1,5-a]pyrimidine-2-carboxaldehyde, 5,7-dimethyl-
• CAS No.: 55293-96-4
• Molecular Formula: C8H8N4O
• Molecular Weight: 176.178
• Hs Code.: 2933990090
• Mol file: 55293-96-4.mol

Synonyms:5,7-Dimethyl-1,2,4-triazolo<1,5-a>pyrimidin-5-carbaldehyd;

Chemical Property of [1,2,4]Triazolo[1,5-a]pyrimidine-2-carboxaldehyde, 5,7-dimethyl-

Chemical Property:

• PSA: 60.15000
• LogP: 0.55360
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5,7-Dimethyl-[1,2,4]triazolo[1,5-A]pyrimidine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [1,2,4]Triazolo[1,5-a]pyrimidine-2-carboxaldehyde, 5,7-dimethyl-

There total 4 articles about [1,2,4]Triazolo[1,5-a]pyrimidine-2-carboxaldehyde, 5,7-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(5,7-dimethyl- [1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol (54535-00-1) → 5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carbaldehyde (55293-96-4)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In dichloromethane; at 20 ℃;

Reference yield:

(5-amino-1H-[1,2,4]triazol-3-yl)-methanol; glycolate (63870-39-3) → 5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carbaldehyde (55293-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / ethanol / Inert atmosphere

2: [bis(acetoxy)iodo]benzene; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 7 h / 33.5 °C / Inert atmosphere; Large scale

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; acetic acid; In ethanol; dichloromethane;

DOI:10.1021/op0600761

Reference yield:

C29H36(2)HN5O3 (1508308-97-1) → 5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carbaldehyde (55293-96-4) + C8H7(2)HN4O (1508308-98-2)

Guidance literature:

With oxygen; at 80 ℃; Kinetics;

DOI:10.1021/op400237j

upstream raw materials:

(5,7-dimethyl- [1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol

(5-amino-1H-[1,2,4]triazol-3-yl)-methanol; glycolate

C₂₉H₃₆⁽²⁾HN₅O₃

Downstream raw materials:

2-[4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)-2-fluorophenyl]-2-methylpropanenitrile

2-[2-chloro-4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)phenyl]-2-methylpropanenitrile

[4-(2-{2-cyclopentyl-5-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl}ethyl)-2-ethylphenyl]acetonitrile

6-cyclopentyl-3-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-6-[2-(5-ethyl-4-hydroxy-2-propoxyphenyl)ethyl]-4-hydroxy-5,6-dihydro-2H-pyran-2-one

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