10.1080/10426500802625594
The research aimed to synthesize new heterocyclic Schiff bases derived from 2-amino-3-formylchromone and investigate their antimicrobial activity. The study focused on combining chromone moieties with 1,2,4-triazole or 1,2,4-triazine derivatives through an azomethine linkage to create novel nitrogen heterocyclic systems. Key chemicals used included 2-amino-3-formylchromone as the starting material, various hydrazine derivatives (such as benzoylhydrazine, cyanoacetohydrazide, and thiocarbohydrazide) for condensation reactions, and electrophilic reagents like benzoyl chloride, acetic anhydride, and carbon disulfide for further heterocyclization. The newly synthesized compounds were characterized using IR, 1H NMR, and mass spectrometry. The antimicrobial activity of these compounds was tested against a range of bacteria and fungi, revealing that compounds 8 and 20 showed moderate activity against bacteria and high activity against fungi, while compounds 9, 13, and 15 exhibited high antifungal activity. The study concluded that the synthesized compounds have potential as antimicrobial agents, particularly those incorporating dithioxo-1,2,4-triazole and antipyrine moieties, and suggested that further modifications could enhance their biological efficacy.
