1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:55507-15-8
Molecular Formula:C17H18ClNO2
Molecular Weight:303.788
Hs Code.:2933499090
DSSTox Substance ID:DTXSID70400654
Nikkaji Number:J2.099.495I
ChEMBL ID:CHEMBL52780
Mol file:55507-15-8.mol

Synonyms:1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline;55507-15-8;CHEMBL52780;Oprea1_403581;Oprea1_749517;AG-690/11548056;SCHEMBL11713299;DTXSID70400654;NYOFLAMHIMULAO-UHFFFAOYSA-N;BDBM50535878;STK903318;AKOS000275799;AKOS016041656;BB 0218162;CS-0222420;EN300-111080;1-(4-Chlorophenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Suppliers and Price of 1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 97%
5g
$ 649.00

Crysdot
1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 97%
10g
$ 882.00

Chemenu
1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 97%
10g
$ 832.00

Chemenu
1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 97%
5g
$ 612.00

American Custom Chemicals Corporation
1-(4-CHLORO-PHENYL)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 95.00%
5MG
$ 499.05

AK Scientific
1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
250mg
$ 291.00

Total 4 raw suppliers

Chemical Property of 1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

PSA：30.49000
LogP:3.92110
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:303.1026065
Heavy Atom Count:21
Complexity:333

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(NCCC2=C1)C3=CC=C(C=C3)Cl)OC

Technology Process of 1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

There total 9 articles about 1-(4-Chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 5467-91-4
1,3-bis[2-(3,4-dimethoxyphenyl)ethyl]urea

: 104-88-1
4-chlorobenzaldehyde

: 55507-15-8
1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: (±)-(R*,R*)-bis(1-(4-chlorophenyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone

Guidance literature:: With p-toluene sulfinic acid; In toluene; at 120 ℃; for 12h; diastereoselective reaction;
DOI:10.1021/acs.jmedchem.5b01448

Reference yield:

: 15994-13-5
N-(4-chlorobenzylidene)-2-(3,4-dimethoxyphenyl)ethanamine

: 55507-15-8
1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: N-(4-chlorobenzylidene)-2-(3,4-dimethoxyphenyl)ethanamine; With trifluoroacetic acid; at 90 ℃; for 0.0833333h; under 10343.2 Torr; Microwave irradiation;

With sodium hydroxide; In water;
DOI:10.1016/j.bmc.2009.03.066

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 55507-15-8
1-(4-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 3 h / Heating

2: TFA / 90 h / Heating

With trifluoroacetic acid; In toluene;
DOI:10.1016/j.farmac.2003.10.003