Imidazo[1,2-a]pyrimidin-5(1H)-one

Base Information

• Chemical Name: Imidazo[1,2-a]pyrimidin-5(1H)-one
• CAS No.: 55662-68-5
• Molecular Formula: C6H5N3O
• Molecular Weight: 135.125
• Hs Code.: 2933990090
• Mol file: 55662-68-5.mol

Synonyms:Imidazo<1,2-a>pyrimidin-2-aethylacetat;imidazo[1,2-a]pyrimidin-2-yl-acetic acid ethyl ester;ethyl 2-{imidazo[1,2-a]pyrimidin-2-yl}acetate;Imidazo<1,2-a>pyrimidin-5(1H)-one;Imidazo<1,2-a>pyrimidin-5-on;imidazolo<1,2-a>pyrimidine-5(1H)-one;1(8)H-imidazo[1,2-a]pyrimidin-5-one;

Chemical Property of Imidazo[1,2-a]pyrimidin-5(1H)-one

Chemical Property:

• Boiling Point: 251.355 °C at 760 mmHg
• Flash Point: 105.816 °C
• PSA: 50.16000
• Density: 1.511 g/cm³
• LogP: 0.02260

Purity/Quality:

99% ^*data from raw suppliers

5H,8H-Imidazo[1,2-a]pyrimidin-5-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyrimidin-5(1H)-one

There total 4 articles about Imidazo[1,2-a]pyrimidin-5(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

isocytosine (108-53-2,145358-63-0,674-97-5,176772-97-7) + 2-bromomalondialdehyde (19263-02-6) → imidazolo<1,2-a>pyrimidine-5(1H)-one (55662-68-5)

Guidance literature:

With sodium hydroxide; In water; at 60 ℃; for 96h; at pH 3.8;

DOI:10.1021/jo00195a030

Reference yield: 37.0%

isocytosine (108-53-2,145358-63-0,674-97-5,176772-97-7) + Bromoacetaldehyde diethyl acetal (2032-35-1) → imidazolo<1,2-a>pyrimidine-5(1H)-one (55662-68-5) + imidazolo<1,2-a>pyrimidine-7(8H)-one (55662-33-4)

Guidance literature:

In water; at 70 ℃; for 48h; also from chloroacetaldehyde diethylacetal;

DOI:10.1248/cpb.40.235

Reference yield:

→ imidazolo<1,2-a>pyrimidine-5(1H)-one (55662-68-5)

Guidance literature:

7-Chlorimidazo<1,2-a>pyrimidin-5-on, waessr. EtOH, NH4OH, H2/Pd-Kohle;

DOI:10.1021/jm00246a018

upstream raw materials:

isocytosine

2-bromomalondialdehyde

Bromoacetaldehyde diethyl acetal

Downstream raw materials:

isocytosine

6-bromoimidazolo<1,2-a>-pyrimidine-5(1H)-one

Refernces

• 1、 Nair, Vasu,Offerman, Rick J.,Turner, Gregory A.. "Structural Alteration of Nucleic Acid Bases by Bromomalonaldehyde". . p. 4021 - 4025. Retrieved 2007/10/02.