2-N-HEXYL-4-PENTYNOIC ACID

Base Information

Chemical Name:2-N-HEXYL-4-PENTYNOIC ACID
CAS No.:96017-59-3
Molecular Formula:C11H18 O2
Molecular Weight:182.26
Hs Code.:2916190090
Mol file:96017-59-3.mol

Synonyms:Octanoicacid, 2-(2-propynyl)- (9CI)

Suppliers and Price of 2-N-HEXYL-4-PENTYNOIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Hexyl-4-pentynoic Acid
1g
$ 120.00

TRC
2-Hexyl-4-pentynoic Acid
2.5g
$ 240.00

TCI Chemical
2-Hexyl-4-pentynoic Acid >95.0%(T)
5g
$ 215.00

TCI Chemical
2-Hexyl-4-pentynoic Acid >95.0%(T)
25g
$ 684.00

Crysdot
2-(Prop-2-yn-1-yl)octanoicacid 97%
25g
$ 461.00

Chem-Impex
2-Hexyl-4-pentynoicacid,95%(Assaybytitration) 95%(Assaybytitration)
5G
$ 238.56

Chem-Impex
2-Hexyl-4-pentynoicacid,95%(Assaybytitration) 95%(Assaybytitration)
25G
$ 885.92

Cayman Chemical
2-hexyl-4-Pentynoic Acid ≥95%
250mg
$ 33.00

Cayman Chemical
2-hexyl-4-Pentynoic Acid ≥95%
5g
$ 165.00

Cayman Chemical
2-hexyl-4-Pentynoic Acid ≥95%
500mg
$ 59.00

Total 12 raw suppliers

Chemical Property of 2-N-HEXYL-4-PENTYNOIC ACID

Chemical Property:

Refractive Index:1.4450-1.4510
Boiling Point:287.1°Cat760mmHg
Flash Point:138.7°C
PSA：37.30000
Density:0.964g/cm³
LogP:2.68090
Storage Temp.:Inert atmosphere,Room Temperature
Solubility.:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Purity/Quality:

97% ^*data from raw suppliers

2-Hexyl-4-pentynoic Acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Description 2-hexyl-4-Pentynoic acid is a derivative of valproic acid , an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 μM) than valproic acid (IC50 = 398 μM). 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 μM. It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 μM.

Technology Process of 2-N-HEXYL-4-PENTYNOIC ACID

There total 5 articles about 2-N-HEXYL-4-PENTYNOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2-(3-(triisopropylsilyl)prop-2-yn-1-yl)octanoic acid

: 96017-59-3
R-2-(2-propynyl)octanoic acid

Guidance literature:: With silver fluoride; In methanol; at 20 ℃; for 24h; Darkness;
DOI:10.1002/anie.202010784

Reference yield: 83.8%

: 716316-58-4
2-hexyl-2-propargylmalonic acid

: 96017-59-3
R-2-(2-propynyl)octanoic acid

Guidance literature:: at 130 ℃; for 3h;
DOI:10.1021/jm0499615

Reference yield:

: 17920-23-9
diethyl propargylmalonate

: 96017-59-3
R-2-(2-propynyl)octanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 41.1 percent / EtONa / ethanol / 6 h / Heating

2: 99 percent / aq. NaOH / ethanol / 3 h / Heating

3: 83.8 percent / 3 h / 130 °C

With sodium hydroxide; sodium ethanolate; In ethanol;
DOI:10.1021/jm0499615