2-Amino-5-methylbenzenesulfonamide

Base Information

• Chemical Name: 2-Amino-5-methylbenzenesulfonamide
• CAS No.: 609-55-2
• Molecular Formula: C7H10N2O2S
• Molecular Weight: 186.235
• Hs Code.: 2935009090
• European Community (EC) Number: 837-476-1
• NSC Number: 57677
• DSSTox Substance ID: DTXSID60288807
• Nikkaji Number: J962.769C
• Wikidata: Q82025897
• Mol file: 609-55-2.mol

Synonyms:2-amino-5-methylbenzenesulfonamide;609-55-2;2-amino-5-methylbenzene-1-sulfonamide;2-amino-5-methyl-benzenesulfonamide;Benzenesulfonamide, 2-amino-5-methyl-;Toluidinsulfamid;NSC57677;SCHEMBL1522533;DTXSID60288807;4-TOLUIDINE-2-SULFONAMIDE;2-amino-5-methyl-benzensulfonamide;2-Amino-5-Methyl Benzenesulfonamide;NSC-57677;AKOS006271435;AM808245;CS-0244344;FT-0694476;EN300-275838;J-507963;Z1198155188;1-(2-METHOXYPHENYL)-4-(3-CHLOROPROPYL)PIPERAZINEDIHYDROCHLORIDE

Chemical Property of 2-Amino-5-methylbenzenesulfonamide

Chemical Property:

• Appearance/Colour: white or offwhite powder
• Vapor Pressure: 9.92E-07mmHg at 25°C
• Melting Point: 118-120oC
• Refractive Index: 1.609
• Boiling Point: 403.8 °C at 760 mmHg
• Flash Point: 198 °C
• PSA: 94.56000
• Density: 1.359 g/cm³
• LogP: 2.58690
• Storage Temp.: 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 186.04629874
• Heavy Atom Count: 12
• Complexity: 245

Purity/Quality:

99.5% ^*data from raw suppliers

2-Amino-5-methylbenzenesulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)N)S(=O)(=O)N

Technology Process of 2-Amino-5-methylbenzenesulfonamide

There total 6 articles about 2-Amino-5-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

7-methyl-3-oxo-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (71254-63-2) → 2-amino-5-methyl-benzenesulfonamide (609-55-2)

Guidance literature:

7-methyl-3-oxo-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; With sulfuric acid; In water; at 105 ℃; for 16h;

With sodium hydroxide; In water; at 0 ℃;

Reference yield: 55.0%

→ 2-amino-5-methyl-benzenesulfonamide (609-55-2)

Guidance literature:

Reference yield:

4-acetylamino-toluene-3-sulfonic acid amide (855941-97-8) → 2-amino-5-methyl-benzenesulfonamide (609-55-2)

Guidance literature:

4-acetylamino-toluene-3-sulfonic acid amide; With hydrogenchloride; water; for 2h; Heating / reflux;

With sodium carbonate; In water; pH=8;

upstream raw materials:

2-amino-4-chloro-5-methyl-benzenesulfonamide

7-methyl-3-oxo-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

N-(p-toluenyl)-N'-(chlorosulfonyl)-urea

p-toluidine

Downstream raw materials:

pazopanib hydrochloride

C₁₇H₁₅F₃N₂O₄S

C₁₇H₁₆BrFN₂O₄S

methyl 2-(7-methyl-1,1-dioxo-2-(2,4,5-trifluorobenzyl)-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate

Refernces

• 1、 Khelili, Smail,Kihal, Nadjib,Yekhlef, Mohamed,De Tullio, Pascal,Lebrun, Philippe,Pirotte, Bernard. "Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1- benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells". scheme or table. p. 873 - 878. Retrieved 2012/09/10.
• 2、 -. "METHODS FOR IDENTIFICATION OF JAK KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF JAK KINASES". Page/Page column 35-36. . Retrieved 2009/06/27.