N-(2-Benzoyl-4-chlorophenyl)-N~2~-hydroxyglycinamide

Base Information

• Chemical Name: N-(2-Benzoyl-4-chlorophenyl)-N~2~-hydroxyglycinamide
• CAS No.: 5624-83-9
• Molecular Formula: C₁₅H₁₃ClN₂O₃
• Molecular Weight: 304.733
• DSSTox Substance ID: DTXSID00500535
• Wikidata: Q82352211
• Mol file: 5624-83-9.mol

Synonyms:5624-83-9;N-(2-Benzoyl-4-chlorophenyl)-N~2~-hydroxyglycinamide;DTXSID00500535;Acetamide, N-(2-benzoyl-4-chlorophenyl)-2-(hydroxyamino)-

Chemical Property of N-(2-Benzoyl-4-chlorophenyl)-N~2~-hydroxyglycinamide

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 304.0614700
• Heavy Atom Count: 21
• Complexity: 372

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=C(C=CC(=C2)Cl)NC(=O)CNO

Technology Process of N-(2-Benzoyl-4-chlorophenyl)-N~2~-hydroxyglycinamide

There total 7 articles about N-(2-Benzoyl-4-chlorophenyl)-N~2~-hydroxyglycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-Iodoacetamido)-5-chlorobenzophenone (17260-11-6) → 5-Chlor-2-(2-hydroxylamino-acetamino)-benzophenon (5624-83-9)

Guidance literature:

With sodium hydroxide; hydroxylamine sulfate; In ethanol;

Reference yield:

5-Chlor-2-(4-brom-benzolsulfonyloxyacetamino)-benzophenon (5628-04-6) → 5-Chlor-2-(2-hydroxylamino-acetamino)-benzophenon (5624-83-9)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; In 2-methoxy-ethanol;

Reference yield:

5-Chlor-2-acetoxyacetamino-benzophenon (5628-00-2) → 5-Chlor-2-(2-hydroxylamino-acetamino)-benzophenon (5624-83-9)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH

2: Et₃N

3: NH₂OH*HCl, aq. NaOH / 2-methoxy-ethanol

With sodium hydroxide; hydroxylamine hydrochloride; triethylamine; In 2-methoxy-ethanol;

upstream raw materials:

2-(2-Iodoacetamido)-5-chlorobenzophenone

5-Chlor-2-(4-brom-benzolsulfonyloxyacetamino)-benzophenon

5-Chlor-2-acetoxyacetamino-benzophenon

2-(Hydroxyacetamido)-5-chlorbenzophenon