5-(2,4-Dichlorophenyl)-2-furaldehyde

Base Information

• Chemical Name: 5-(2,4-Dichlorophenyl)-2-furaldehyde
• CAS No.: 56300-69-7
• Molecular Formula: C11H6Cl2O2
• Molecular Weight: 241.073
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID90350162
• Nikkaji Number: J3.383.957J
• Wikidata: Q82125958
• ChEMBL ID: CHEMBL4536974
• Mol file: 56300-69-7.mol

Synonyms:5-(2,4-dichlorophenyl)-2-furaldehyde;56300-69-7;5-(2,4-dichlorophenyl)furan-2-carbaldehyde;5-(2,4-Dichlorophenyl)furfural;5-(2 4-Dichlorophenyl)furfural 97;5-(2,4-dichlorophenyl)-2-furancarboxaldehyde;SCHEMBL1728691;CHEMBL4536974;DTXSID90350162;WTXWLFKNQYWFPK-UHFFFAOYSA-N;MFCD00141622;STK056864;AKOS000108217;SB61462;5-(2,4-Dichlorophenyl)furfural, 97%;BB 0245473;CS-0116927;FT-0679299;EN300-31046;5F-045;5-(2,4-Dichloro-phenyl)-furan-2-carbaldehyd e;J-516080;Z57313835

Chemical Property of 5-(2,4-Dichlorophenyl)-2-furaldehyde

Chemical Property:

• Vapor Pressure: 2.33E-05mmHg at 25°C
• Melting Point: 158-163oC(lit.)
• Boiling Point: 359.7oC at 760 mmHg
• Flash Point: 171.3oC
• PSA: 30.21000
• Density: 1.392g/cm3
• LogP: 4.06590
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 239.9744848
• Heavy Atom Count: 15
• Complexity: 235

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-(2,4-Dichlorophenyl)-2-furaldehyde ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)C2=CC=C(O2)C=O

Technology Process of 5-(2,4-Dichlorophenyl)-2-furaldehyde

There total 4 articles about 5-(2,4-Dichlorophenyl)-2-furaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

furfural (98-01-1) + 2,4 dichlorobenzoic acid (50-84-0) → 5-(2,4-dichlorophenyl)furfural (56300-69-7)

Guidance literature:

With palladium(II) trifluoroacetate; triphenylphosphine; silver carbonate; In 1,2-dimethoxyethane; dimethyl sulfoxide; at 120 ℃; for 24h; Inert atmosphere; Glovebox;

DOI:10.1002/ejoc.201402278

Reference yield: 70.0%

furfural (98-01-1) + 2,4-Dichloroaniline (554-00-7,51908-09-9) → 5-(2,4-dichlorophenyl)furfural (56300-69-7)

Guidance literature:

2,4-Dichloroaniline; With hydrogenchloride; water; sodium nitrite; at 0 - 5 ℃;

furfural; With ammonium cerium(IV) nitrate; In water; at 20 ℃; for 7h;

Reference yield: 53.0%

5-formylfurane-2-boronic acid (27329-70-0) + 2,4-dichloro-1-iodo-benzene (29898-32-6) → 5-(2,4-dichlorophenyl)furfural (56300-69-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 65 ℃; for 1h;

DOI:10.1016/j.ejmech.2016.12.024

upstream raw materials:

furfural

2,4-Dichloroaniline

2,4 dichlorobenzoic acid

5-formylfurane-2-boronic acid

Downstream raw materials:

3-[5-(2,4-dichlorophenyl)-2-furanyl]-3-hydroxypropanoic acid

5-(2',4'-dichlorophenyl)furan-2-carbaldehyde oxime