2-(4-Methoxyphenyl)-5-(3-pyridinyl)-1,3,4-oxadiazole

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-5-(3-pyridinyl)-1,3,4-oxadiazole
• CAS No.: 56352-93-3
• Molecular Formula: C14H11N3O2
• Molecular Weight: 253.26
• DSSTox Substance ID: DTXSID40357722
• Nikkaji Number: J3.542.044D
• Wikidata: Q27192847
• ChEMBL ID: CHEMBL1385182

Synonyms:2-(4-methoxyphenyl)-5-(3-pyridinyl)-1,3,4-oxadiazole;56352-93-3;2-(4-methoxyphenyl)-5-pyridin-3-yl-1,3,4-oxadiazole;MLS-0073079.0001;ST070527;Oprea1_129508;Oprea1_207441;MLS000067760;cid_865615;SCHEMBL1423243;CHEMBL1385182;BDBM64805;DTXSID40357722;CHEBI:112731;3-[5-(4-Methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-pyridine;HMS2372N05;NSC782224;AKOS000730298;NSC-782224;SMR000122316;Q27192847;2-(4-methoxyphenyl)-5-(3-pyridyl)-1,3,4-oxadiazole

Chemical Property of 2-(4-Methoxyphenyl)-5-(3-pyridinyl)-1,3,4-oxadiazole

Chemical Property:

• PSA: 61.04000
• LogP: 2.80720
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 253.085126602
• Heavy Atom Count: 19
• Complexity: 282

Purity/Quality:

2-(4-METHOXYPHENYL)-5-(PYRIDIN-3-YL)-1,3,4-OXADIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NN=C(O2)C3=CN=CC=C3

Technology Process of 2-(4-Methoxyphenyl)-5-(3-pyridinyl)-1,3,4-oxadiazole

There total 6 articles about 2-(4-Methoxyphenyl)-5-(3-pyridinyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(E)-N'-(4-methoxybenzylidene)pyridine-3-carbohydrazide (100867-76-3) → 2-(4''-methoxyphenyl)-5-(3'-pyridinyl)-1,3,4-oxadiazole (56352-93-3)

Guidance literature:

With bis-[(trifluoroacetoxy)iodo]benzene; In chloroform; at 20 ℃; for 0.05h;

DOI:10.1080/00397910600773650

Reference yield: 81.0%

Nicotinic acid hydrazide (553-53-7) + 4-methoxybenzoic acid (100-09-4) → 2-(4''-methoxyphenyl)-5-(3'-pyridinyl)-1,3,4-oxadiazole (56352-93-3)

Guidance literature:

With aluminum oxide; trichlorophosphate; Microwave irradiation;

DOI:10.1007/s00044-013-0588-2

Reference yield: 48.0%

C14H15N3O2 → 2-(4''-methoxyphenyl)-5-(3'-pyridinyl)-1,3,4-oxadiazole (56352-93-3)

Guidance literature:

With [bis(acetoxy)iodo]benzene; at 40 ℃; for 2h;

DOI:10.1055/s-0034-1379974

upstream raw materials:

N'-(4-methoxybenzoyl)nicotinohydrazide

(E)-N'-(4-methoxybenzylidene)pyridine-3-carbohydrazide

Nicotinic acid hydrazide

4-methoxybenzoic acid

Downstream raw materials:

3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-6-bromo-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole

3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-4-nitro-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole

3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-5,6-dichloro-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole

3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-6-methyl-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole

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