2-amino-1-(1-piperidinyl)Ethanone

Base Information

• Chemical Name: 2-amino-1-(1-piperidinyl)Ethanone
• CAS No.: 5649-08-1
• Molecular Formula: C7H14N2O
• Molecular Weight: 142.201
• Mol file: 5649-08-1.mol

Synonyms:2-amino-1-piperidin-1-yl-ethanone;1-glycyl-piperidine;2-amino-1-(piperidin-1-yl)ethanone;2-amino-1-piperidin-1-ylethanone;1-Glycyl-piperidin;1-Glycylpiperidin;

Chemical Property of 2-amino-1-(1-piperidinyl)Ethanone

Chemical Property:

• Boiling Point: 83 - 85 °C (3 mmHg)
• PSA: 46.33000
• LogP: 0.59580

Purity/Quality:

95% ^*data from raw suppliers

2-Amino-1-piperidin-1-yl-ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-1-(1-piperidinyl)Ethanone

There total 6 articles about 2-amino-1-(1-piperidinyl)Ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-oxo-2-(piperidin-1-yl)ethyl-carbamic acid benzyl ester (3886-37-1) → 2-amino-1-(piperidin-1-yl)ethan-1-one (5649-08-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h; under 760.051 Torr;

DOI:10.1016/j.bmc.2010.12.007

Reference yield: 97.0%

→ 2-amino-1-(piperidin-1-yl)ethan-1-one (5649-08-1)

Guidance literature:

Reference yield: 29.0%

piperidine (110-89-4) + glycine tert-butyl ester hydrochloride (27532-96-3) → 2-amino-1-(piperidin-1-yl)ethan-1-one (5649-08-1)

Guidance literature:

piperidine; glycine tert-butyl ester hydrochloride; With benzotriazol-1-ol; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 18h;

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 1h; Alkaline aqueous solution;

upstream raw materials:

piperidine

glycine tert-butyl ester hydrochloride

N-<((tert-butoxycarbonyl)amino)acetyl>piperidine

2-oxo-2-(piperidin-1-yl)ethyl-carbamic acid benzyl ester

Downstream raw materials:

[1-benzyl-3,3-difluoro-2-hydroxy-3-(2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-propyl]-carbamic acid benzyl ester

[4-(2-oxo-2-piperidin-1-yl-ethylsulfamoyl)-phenoxy]-acetic acid tert-butyl ester

C₂₇H₂₉N₃O₄

benzyl (1S,2S)-1-[2-oxo-2-(piperidin-1-yl)ethylcarbamoyl]-2-methylbutylcarbamate