Malonic acid hydrogen 1-isopropyl ester

Base Information

• Chemical Name: Malonic acid hydrogen 1-isopropyl ester
• CAS No.: 56766-77-9
• Molecular Formula: C6H10O4
• Molecular Weight: 146.143
• Mol file: 56766-77-9.mol

Synonyms:Malonsaeuremonoisopropylester;monoisopropyl malonate;iso-propyl malonate;i-propyl malonic half ester;iso-propyl malonic acid;

Chemical Property of Malonic acid hydrogen 1-isopropyl ester

Chemical Property:

• PSA: 66.43000
• LogP: -0.92200

Purity/Quality:

98% ^*data from raw suppliers

Malonicacidmonoisopropylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Malonic acid hydrogen 1-isopropyl ester

There total 5 articles about Malonic acid hydrogen 1-isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cycl-isopropylidene malonate (2033-24-1) + isopropyl alcohol (67-63-0,8013-70-5) → i-propyl malonic half ester (56766-77-9)

Guidance literature:

In acetonitrile; for 22h; Heating;

DOI:10.1016/S0040-4020(00)01164-9

Reference yield: 65.0%

→ i-propyl malonic half ester (56766-77-9)

Guidance literature:

Reference yield:

diisopropyl malonate (13195-64-7) → i-propyl malonic half ester (56766-77-9)

Guidance literature:

With potassium hydroxide; In tert-butyl alcohol;

DOI:10.1007/BF00542785

upstream raw materials:

diisopropyl malonate

cycl-isopropylidene malonate

isopropyl alcohol

malonic acid

Downstream raw materials:

17β-(3-benzyloxyoestra-1,3,5(10)-trienyl) isopropyl malonate

isopropyl cinnamate

isopropyl p-hydroxycinnamate

isopropyl p-methoxycinnamate

Refernces

• 1、 Kumar, Nivesh,Das, Mrinal Kanti,Ghosh, Santanu,Bisai, Alakesh. "Development of catalytic deacylative alkylations (DaA) of 3-acyl-2-oxindoles: total synthesis of meso-chimonanthine and related alkaloids". supporting information. p. 2170 - 2173. Retrieved 2017/02/19.
• 2、 Wang, Huan,Wei, Qing-Yi,Jiang, Hong,Jiang, Zhen-Hua. "One-pot preparation of phenylpropanoid esters co-catalyzed by boric acid and piperidine". experimental part. p. 207 - 213. Retrieved 2012/05/20.