1-Iodo-5,6,7,8-tetrahydronaphthalene

Base Information

• Chemical Name: 1-Iodo-5,6,7,8-tetrahydronaphthalene
• CAS No.: 56804-95-6
• Molecular Formula: C10H11I
• Molecular Weight: 258.09900
• Mol file: 56804-95-6.mol

Synonyms:5-iodo-1,2,3,4-tetrahydro-naphthalene;Naphthalene, 1,2,3,4-tetrahydro-5-iodo-;1-iodotetrahydronaphthalene;5-iodo-1,2,3,4-tetrahydronaphthalene;5-Jod-1,2,3,4-tetrahydro-naphthalin;

Chemical Property of 1-Iodo-5,6,7,8-tetrahydronaphthalene

Chemical Property:

• Boiling Point: 279 - 280 °C (765 mmHg)
• PSA: 0.00000
• LogP: 3.17000

Purity/Quality:

98% ^*data from raw suppliers

5-Iodo-1,2,3,4-tetrahydro-naphthalene 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Iodo-5,6,7,8-tetrahydronaphthalene

There total 1 articles about 1-Iodo-5,6,7,8-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

1,2-diethynylcyclohex-1-ene (21336-06-1) → 1,2-bis-(1-iodo-vinyl)-cyclohexene + 1-iodo-5,6,7,8-tetrahydronaphthalene (56804-95-6)

Guidance literature:

With hydrogen iodide; In water; at 100 ℃; for 1h;

DOI:10.1021/jo0518295

Reference yield: 94.0%

1-iodo-5,6,7,8-tetrahydronaphthalene (56804-95-6) + 2-bromo-N-(2-(tert-butyl)phenyl)-3-methylbenzamide → 5-(2-(tert-butyl)phenyl)-10-methyl-2,3,4,5-tetrahydrobenzo[c]phenanthridin-6(1H)-one

Guidance literature:

With trifuran-2-yl-phosphane; palladium diacetate; (1S,4R)-2-norbornene-2-carboxylic acid ethyl ester; potassium carbonate; In acetonitrile; at 70 ℃; for 24h; enantioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1016/j.chempr.2021.04.005

Reference yield: 55.0%

4'-methylbenzoyl 2,3,4,6-tetra-O-acetyl-β-D-selenoglucopyranoside (869107-17-5) + 1-iodo-5,6,7,8-tetrahydronaphthalene (56804-95-6) → (2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-((2-(4-methylbenzoyl)-5,6,7,8-tetrahydronaphthalen-1-yl)selanyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Guidance literature:

With 1,3-dimethyl-2-imidazolidinone; dichloro bis(acetonitrile) palladium(II); bicyclo[2.2.1]hept-5-ene-2-carbonitrile; potassium carbonate; tri(4-chlorophenyl)phosphine; at 95 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c01723

upstream raw materials:

1,2-diethynylcyclohex-1-ene

Refernces