Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-[[(2S)-2-amino-1-oxopropyl]amino]-3-[(3,4-dichlorophenyl)methoxy]-6- fluoro-, (1R,2R,3R,5R,6R)-

Base Information

Chemical Name:Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-[[(2S)-2-amino-1-oxopropyl]amino]-3-[(3,4-dichlorophenyl)methoxy]-6- fluoro-, (1R,2R,3R,5R,6R)-
CAS No.:569687-16-7
Molecular Formula:C18H19Cl2FN2O6
Molecular Weight:449.263
Hs Code.:

Synonyms:

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Chemical Property of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-[[(2S)-2-amino-1-oxopropyl]amino]-3-[(3,4-dichlorophenyl)methoxy]-6- fluoro-, (1R,2R,3R,5R,6R)-

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MSDS Files:: SDS file from LookChem

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Technology Process of Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-[[(2S)-2-amino-1-oxopropyl]amino]-3-[(3,4-dichlorophenyl)methoxy]-6- fluoro-, (1R,2R,3R,5R,6R)-

There total 2 articles about Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-[[(2S)-2-amino-1-oxopropyl]amino]-3-[(3,4-dichlorophenyl)methoxy]-6- fluoro-, (1R,2R,3R,5R,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 892494-27-8
(1R,2R,3R,5R,6R)-2-((2S)-2-tert-butoxycarbonylaminopropionylamino)-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester

: 569687-16-7
(1R,2R,3R,5R,6R)-2-((2S)-2-aminopropionylamino)-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid

Guidance literature:: (1R,2R,3R,5R,6R)-2-((2S)-2-tert-butoxycarbonylaminopropionylamino)-3-(3,4-dichlorobenzyloxy)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester; With lithium hydroxide; In water; at 20 ℃;

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 15h;
DOI:10.1016/j.bmc.2006.01.060