Benzene, 1-(methoxymethoxy)-3-methyl-

Base Information

• Chemical Name: Benzene, 1-(methoxymethoxy)-3-methyl-
• CAS No.: 57234-27-2
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• DSSTox Substance ID: DTXSID20449977
• Nikkaji Number: J1.625.170D
• Wikidata: Q82269531
• Mol file: 57234-27-2.mol

Synonyms:1-(methoxymethoxy)-3-methylbenzene;3-(methoxymethoxy)toluene;57234-27-2;SCHEMBL761063;DTXSID20449977;PEQIXJICXMPXKH-UHFFFAOYSA-N;AKOS014700257;FT-0753459

Chemical Property of Benzene, 1-(methoxymethoxy)-3-methyl-

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 104

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC=C1)OCOC

Technology Process of Benzene, 1-(methoxymethoxy)-3-methyl-

There total 3 articles about Benzene, 1-(methoxymethoxy)-3-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Dimethoxymethane (109-87-5) + 3-methyl-phenol (108-39-4) → 1-(methoxymethoxy)-3-methylbenzene (57234-27-2)

Guidance literature:

With zirconyl triflate; at 20 ℃; for 0.166667h; chemoselective reaction; neat (no solvent);

DOI:10.1007/s00706-010-0310-8

Reference yield: 96.0%

chloromethyl methyl ether (107-30-2) + 3-methyl-phenol (108-39-4) → 1-(methoxymethoxy)-3-methylbenzene (57234-27-2)

Guidance literature:

3-methyl-phenol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

chloromethyl methyl ether;

Reference yield:

sodium 3-methylphenoxide (3019-89-4) + chloromethyl methyl ether (107-30-2) → 1-(methoxymethoxy)-3-methylbenzene (57234-27-2)

Guidance literature:

With ethanol;

upstream raw materials:

sodium 3-methylphenoxide

chloromethyl methyl ether

3-methyl-phenol

Dimethoxymethane

Downstream raw materials:

methyl 2-(methoxymethoxy)-4-methylbenzoate

methyl 2-O-methoxymethyl-6-methylsalicylate

6-methyl-3-methylene-2,3-dihydrobenzofuran-2-ol