1-cyclohexyl-4-[(1R)-1,2-diphenylethyl]piperazine

Base Information

• Chemical Name: 1-cyclohexyl-4-[(1R)-1,2-diphenylethyl]piperazine
• CAS No.: 57377-70-5
• Molecular Formula: C₂₄H₃₂N₂
• Molecular Weight: 348.531
• DSSTox Substance ID: DTXSID70388822

Synonyms:(R)-(-)-MT-45 (hydrochloride);AC1MIHGB;57377-70-5;SCHEMBL16226689;DTXSID70388822

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Chemical Property of 1-cyclohexyl-4-[(1R)-1,2-diphenylethyl]piperazine

Chemical Property:

• XLogP3: 5.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 348.256549029
• Heavy Atom Count: 26
• Complexity: 383

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)N2CCN(CC2)C(CC3=CC=CC=C3)C4=CC=CC=C4
• Isomeric SMILES: C1CCC(CC1)N2CCN(CC2)[C@H](CC3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 1-cyclohexyl-4-[(1R)-1,2-diphenylethyl]piperazine

There total 2 articles about 1-cyclohexyl-4-[(1R)-1,2-diphenylethyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-1-cyclohexyl-4-<2-(3-nitrophenyl)-1-phenylethyl>piperazine dihydrochloride (109390-25-2) → (R)-(-)-1-cyclohexyl-4-(1,2-diphenylethyl)piperazine (57377-70-5,41537-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, AcOH / 5percent Pd/C

2: 1.) 31.5percent aq. H₂SO₄, aq. NaNO₂, 2.) 30percent aq. H₃PO₂ / 1.) from 0 deg C to 5 deg C, 10 min

With sulfuric acid; hydrogen; hypophosphorous acid; acetic acid; sodium nitrite; palladium on activated charcoal;

DOI:10.1021/jm00393a017

Reference yield:

(-)-1-cyclohexyl-4-<2-(3-aminophenyl)-1-phenylethyl>piperazine (109364-53-6) → (R)-(-)-1-cyclohexyl-4-(1,2-diphenylethyl)piperazine (57377-70-5,41537-67-1)

Guidance literature:

With sulfuric acid; hypophosphorous acid; sodium nitrite; Yield given. Multistep reaction; 1.) from 0 deg C to 5 deg C, 10 min;

DOI:10.1021/jm00393a017

upstream raw materials:

(-)-1-cyclohexyl-4-<2-(3-aminophenyl)-1-phenylethyl>piperazine

(-)-1-cyclohexyl-4-<2-(3-nitrophenyl)-1-phenylethyl>piperazine dihydrochloride