Thiophene, 2,5-dihydro-3-(4-methoxyphenyl)-, 1,1-dioxide

Base Information

Chemical Name:Thiophene, 2,5-dihydro-3-(4-methoxyphenyl)-, 1,1-dioxide
CAS No.:57465-41-5
Molecular Formula:C11H12O3S
Molecular Weight:224.28
Hs Code.:
DSSTox Substance ID:DTXSID10545634
Nikkaji Number:J914.190A
Wikidata:Q82423192

Synonyms:57465-41-5;Thiophene, 2,5-dihydro-3-(4-methoxyphenyl)-, 1,1-dioxide;SCHEMBL3743725;DTXSID10545634;AKOS002681229;3-(4-Methoxyphenyl)-2,5-dihydro-1H-1lambda~6~-thiophene-1,1-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Thiophene, 2,5-dihydro-3-(4-methoxyphenyl)-, 1,1-dioxide

Chemical Property:

XLogP3:1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:224.05071541
Heavy Atom Count:15
Complexity:343

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=CCS(=O)(=O)C2

Technology Process of Thiophene, 2,5-dihydro-3-(4-methoxyphenyl)-, 1,1-dioxide

There total 6 articles about Thiophene, 2,5-dihydro-3-(4-methoxyphenyl)-, 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: 157141-28-1
3-(tributylstannyl)-3-sulfolene

: 57465-41-5
3-(4-methoxyphenyl)-2,5-dihydrothiophene-1,1-dioxide

Guidance literature:: bis[1,2-bis(diphenylphosphino)ethane]palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 12h;
DOI:10.1055/s-1997-1020

Reference yield: 74.0%

: 31254-20-3
3-hydroxy-3-(4-methoxyphenyl)-but-1-ene

: 57465-41-5
3-(4-methoxyphenyl)-2,5-dihydrothiophene-1,1-dioxide

Guidance literature:: 3-hydroxy-3-(4-methoxyphenyl)-but-1-ene; With 4-(dimethylamino)-1-sulfano-pyridinium; In acetonitrile; at 20 ℃; for 0.25h; Sealed tube; Inert atmosphere;

With methanesulfonyl chloride; In acetonitrile; at 0 - 70 ℃; for 12h; Sealed tube; Inert atmosphere;
DOI:10.1055/s-0034-1380508

Reference yield: 65.9%

: 77-79-2
3-Sulfolene

: 696-62-8
para-iodoanisole

: 57465-41-5
3-(4-methoxyphenyl)-2,5-dihydrothiophene-1,1-dioxide

Guidance literature:: With triethylamine; palladium diacetate; tetrabutylammomium bromide; In benzene; for 90h; Ambient temperature;
DOI:10.1016/S0040-4039(00)95764-2