4-Chloro-3-(2-chloroethyl)-8-methoxy-2-methylquinoline

Base Information

• Chemical Name: 4-Chloro-3-(2-chloroethyl)-8-methoxy-2-methylquinoline
• CAS No.: 57521-19-4
• Molecular Formula: C13H13Cl2NO
• Molecular Weight: 270.15400
• DSSTox Substance ID: DTXSID001326180
• ChEMBL ID: CHEMBL1305644
• Mol file: 57521-19-4.mol

Synonyms:4-chloro-3-(2-chloroethyl)-8-methoxy-2-methylquinoline;57521-19-4;4-chloro-3-(2-chloroethyl)-2-methyl-8-quinolinyl methyl ether;MLS000720591;SMR000336339;Bionet2_001177;SCHEMBL9685516;CHEMBL1305644;BDBM76303;cid_3332664;SMBVDPXPBHJOGJ-UHFFFAOYSA-N;DTXSID001326180;HMS1367F11;HMS2732P20;MFCD03617788;AKOS005081370;12T-0200;2-Methyl-3-(2-chloroethyl)-4-chloro-8-methoxyquinoline;4-chloro-3-(2-chloroethyl)-8-methoxy-2-methyl-quinoline;4-chloranyl-3-(2-chloroethyl)-8-methoxy-2-methyl-quinoline

Chemical Property of 4-Chloro-3-(2-chloroethyl)-8-methoxy-2-methylquinoline

Chemical Property:

• Melting Point: 150 - 150.5 °C (ethanol)
• PSA: 22.12000
• LogP: 3.98650
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 269.0374194
• Heavy Atom Count: 17
• Complexity: 252

Purity/Quality:

4-Chloro-3-(2-chloroethyl)-2-methyl-8-quinolinyl methyl ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C(=C2C=CC=C(C2=N1)OC)Cl)CCCl

Technology Process of 4-Chloro-3-(2-chloroethyl)-8-methoxy-2-methylquinoline

There total 3 articles about 4-Chloro-3-(2-chloroethyl)-8-methoxy-2-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[1-(2-methoxy-phenylimino)-ethyl]-dihydro-furan-2-one (64745-43-3) → 4-chloro-3-(2-chloro-ethyl)-8-methoxy-2-methyl-quinoline (57521-19-4)

Guidance literature:

With trichlorophosphate; at 150 ℃; im Rohr;

Reference yield:

3-acetyl-2-oxo-4,5-dihydrofuran (517-23-7,594837-91-9,98634-97-0,313643-49-1) → 4-chloro-3-(2-chloro-ethyl)-8-methoxy-2-methyl-quinoline (57521-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: phosphoryl chloride / 150 °C / im Rohr

With ethanol; trichlorophosphate;

Reference yield:

2-methoxy-phenylamine (90-04-0) → 4-chloro-3-(2-chloro-ethyl)-8-methoxy-2-methyl-quinoline (57521-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: phosphoryl chloride / 150 °C / im Rohr

With ethanol; trichlorophosphate;

upstream raw materials:

3-[1-(2-methoxy-phenylimino)-ethyl]-dihydro-furan-2-one

3-acetyl-2-oxo-4,5-dihydrofuran

2-methoxy-phenylamine

Downstream raw materials:

1-(2-methylphenyl)-4-methyl-6-methoxy-2,3-dihydropyrrolo[3,2-c]quinoline

6-Methoxy-4,5-dimethyl-1-o-tolyl-2,3-dihydro-1H-pyrrolo[3,2-c]quinolin-5-ium; iodide

1-benzyl-6-methoxy-4-methyl-2,3-dihydropyrrolo<3,2-c>quinoline

6-methoxy-4-methyl-1-phenyl-2,3-dihydro-1H-pyrrolo[3,2-c]quinoline